Diabetes in subjects with hepatocyte nuclear factor (HNF)-1 gene mutations (maturity-onset diabetes of the young [MODY]-3) is characterized by impaired insulin secretion. Surprisingly, MODY3 patients exhibit hypersensitivity to the hypoglycemic actions of sulfonylurea therapy. To study the pharmacogenetic mechanism(s), we have investigated glibenclamide-induced insulin secretion, glibenclamide ...

OBJECTIVE To evaluate whether treatment with insulin in recently diagnosed type 2 diabetes is advantageous compared with glibenclamide treatment. RESEARCH DESIGN AND METHODS Beta-cell function, glycemic control, and quality of life were monitored over 2 years in 39 patients with islet cell antibody-negative type 2 diabetes diagnosed 0-2 years before inclusion in a Swedish multicenter randomiz...

BACKGROUND/AIMS Non-alcoholic fatty liver disease (NAFLD), the major hepatic manifestation of type 2 diabetes mellitus, is the most common liver disease in the US. Thiazolidinediones, a commonly used drug class for the treatment of type 2 diabetes, have emerged as a potentially useful treatment for NAFLD. There are, however, lingering concerns about their potential toxicity as well as emerging ...

b a ckground: the objective was to investigate the relationship between serum interleukin-18 (il-18), pentraxin 3 (ptx3), and high-sensitivity c-reactive protein (hs-crp) levels with body mass index (bmi) and abdominal obesity and also the interaction between genetic variants of apolipoprotein a-ii (apo a-ii) and obesity on the levels of these factors in type 2 diabetes patients (t2d). m ethods...

Diabetes mellitus is a chronic metabolic disorder and becoming the world’s third “killer” together with cancer, cerebro cardiovascular diseases due to its wide spread prevalence, morbidity mortality. Modern anti-diabetic agents produce undesirable adverse effects. As result, alternative therapy required. A shift towards marine natural products desperately needed. Hence, this research was carrie...

background: nutritional education is a necessity in diabetic patients to better control of the disease. the aim of this study was to determine the effectiveness of educational programs to promote nutritional knowledge in type ii diabetes patients using the health belief model (hbm). methods: this was a quasi-experimental study which was performed among type ii diabetic patients referred to rura...

background: type ii diabetes is the most prevalent disease with numerous complications. adherence to treatment is an effective role on promoting health outcomes. this study aimed to assess the cognitive adaptation in treatment adherence and its relative factors in coping with disease among type ii diabetic patients. methods: this was a cross-sectional study which was conducted in 2012. study po...

Diabetes mellitus is a disease characterized by elevated blood sugar levels, one of which often exposed to free radicals. The purpose this study was determine the effects hypoglycemia and ethanol extract on black cumin seeds. This may affect reduction in glucose levels increase weight gain food intake induced alloxan laboratory rats.
 an experimental using only post-test class design. Subj...

purpose: to evaluate color vision in patients with type ii diabetes mellitus without diabetic retinopathy and compare the results with those of age- and sex- matched normal individuals. methods: this descriptive, comparative study was conducted on 100 diabetic patients without any sign of retinopathy and 100 age- and sex-matched normal subjects. color vision was evaluated using ishihara and far...

introduction:diabetes is a significant and expensive health problem which had influenced all the ages in almost all the countries. increasing prevalence of this disease has been caused by continued changes in lifestyle such as unsuitable nutrition, lack of physical activities and fatness which is often related to modern city life, mechanization and industrialization. it is an expensive disease,...