A protein's life inside a cell is usually terminated by the action of proteases that hydrolyse the polypeptide to small peptides or free amino acids. Many proteolytic enzymes are specific for only a few protein substrates, or they mediate highly specialized functions. Promiscuous proteases with broad specificities, however, are generally seques-tered and reside within specialized organelles kno...

INTRODUCTION Human antimicrobial peptides are of interest for the development of positron emission tomography (PET) tracers as they exhibit desirable characteristics that make them good candidates for targeting vectors. Due to their natural role in the innate immune system they selectively bind to pathogenic bacteria and yeast, whilst remaining minimally immunogenic and cytotoxic to humans. Res...

The goal of this research was to investigate the potential of newly synthesized gold complex trichloro(2,4,6-trimethylpyridine)Au(III) as an anticancer agent. The gold(III) complex was synthesized and grafted on nanoporous silica, MCM-41, to produce AuCl(3)@PF-MCM- 41 (AuCl(3) grafted on pyridine-functionalized MCM-41). The toxicity of trichloro(2,4,6- trimethylpyridine)Au(III) and AuCl(3)@PF-M...

2000 unknown 19 164 2001 unknown 29 232 53 41 2002 unknown 36 327 24 41 2003 unknown 45 385 25 18 2004 unknown 32 379 -29 -2 2005 unknown 44 492 38 3

The experiment was laid out at Agricultural College and Research Institute, Madurai, Tamil Nadu. India and the materials for this study consisted of three TGMS lines viz., TS 29, TS 6 and GD 98013 and 11 testers viz., ADT 39, ADT 41, Pusa Basmathi 1, Basmathi 370, Improved White ponni, AD 98028, GEB 24, ADT 43, ADT 45, Taroari Basmathi and Jeeraga samba. Crossing was done according to clipping ...

Null mutations in the C. elegans heterochronic gene lin-41 cause precocious expression of adult fates at larval stages. Increased lin-41 activity causes the opposite phenotype, reiteration of larval fates. let-7 mutations cause similar reiterated heterochronic phenotypes that are suppressed by lin-41 mutations, showing that lin-41 is negatively regulated by let-7. lin-41 negatively regulates th...