نتایج جستجو برای: ucn
تعداد نتایج: 640 فیلتر نتایج به سال:
Surgical interventions for vesicoureteral reflux (VUR) include open or laparoscopic ureterocystoneostomy (UCN) and endoscopic injection. Historically, open UCN has been the gold standard in surgical treatment of VUR with high success and low complication rates. [1] Although open UCN causes bleeding from the incised bladder wall or dissected trigone, the bleeding is usually not severe unless a b...
In this paper, we describe the performance of the Los Alamos spallation-driven solid-deuterium ultra-cold neutron (UCN) source. Measurements of the cold neutron flux, the very low energy neutron production rate, and the UCN rates and density at the exit from the biological shield are presented and compared to Monte Carlo predictions. The cold neutron rates compare well with predictions from the...
A silicon ultracold neutron (UCN) detector with an area of 45 cm(2) and with a (6)LiF converter is developed at St. Petersburg Nuclear Physics Institute (PNPI). The spectral efficiency of the silicon UCN detector was measured by means of a gravitational spectrometer at Institut Max von Laue - Paul Langevin (ILL). The sandwich-type detector from two silicon plates with a (6)LiF converter placed ...
Proposals exist and efforts are under way to construct pulsed spallation ultra-cold neutron (UCN) sources at accelerator laboratories around the world. At the Paul Scherrer Institut (PSI), Switzerland, and at the Los Alamos National Laboratory (LANL), U.S.A., it is planned to use solid deuterium (SD2) for the UCN production from cold neutrons. The philosophies about how the cold neutrons are ob...
Urocortin (UCN), a newly identified corticotrophin-releasing-factor (CRF) related peptide, has been demonstrated to play important roles in female reproductive system. However, few studies were reported about its effects on male reproduction. This study aimed to investigate the expression profile of UCN and CRF receptors (CRFR) in mouse testis and functions of UCN in male reproduction. Expressi...
The corticotropin-releasing hormone (CRH) system, including CRH and urocortin (UCN), is implicated in the central control of appetite and energy metabolism. Urocortin, a recently isolated neuropeptide closely related to CRH is involved in the central signaling cascade that inhibits energy intake. When administered intracerebroventricularly and intra-hypothalamically, UCN potently decreases food...
Urocortin (Ucn) is an endogenous cardioprotective agent that protects against the damaging effects of ischemia and reperfusion injury in vitro and in vivo. We have found that the mechanism of action of Ucn involves both acute activation of specific target molecules, and using Affymetrix (Santa Clara, CA) gene chip technology, altered gene expression of different end effector molecules. Here, fr...
In sheep with HF (heart failure), Ucn 1 (urocortin 1) decreases total peripheral resistance and left atrial pressure, and increases cardiac output in association with attenuation of vasopressor hormone systems and enhancement of renal function. In a previous study, we demonstrated in the first human studies that infusion of Ucn 1 elevates corticotropin ('ACTH'), cortisol and ANP (atrial natriur...
Urocortin (UCN), a member of the corticotrophin-releasing factor family, is expressed in heart, brain and gut. UCN has potent cardiostimulatory, cardioprotective, vasodilator and diuretic/natriuretic effects, and cardiac UCN expression is increased in heart failure (HF). In the present study, we investigated plasma levels of UCN in 119 patients with HF and 212 age- and gender-matched controls t...
Interactions between pharmacologic NF-kappaB inhibitors (eg, Bay 11-7082, SN-50) and the checkpoint abrogator UCN-01 have been examined in human multiple myeloma (MM) cells. Exposure of U266 cells to Bay 11-7082 (Bay) in combination with UCN-01 resulted in the abrogation of NF-kappaB/DNA binding activity and the synergistic induction of apoptosis. Comparable synergism was observed in other MM c...
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