Infection of the stomach and proximal duodenum with Helicobacter pylori induces inflammation with associated changes in the mucosa. Alterations in mucus structure and function, surface epithelial cell integrity, mucosal blood flow, and local mucosal neural and hormonal status have been observed following this infection. A proportion of subjects infected with H pylori develop duodenal ulcer dise...

BACKGROUND AND AIMS Factors predisposing to endoscopic ulcer formation or healing with non-steroidal anti-inflammatory drugs (NSAIDs) have not been well defined. METHODS We used multivariate analysis of data from three large similar trials to identify factors associated with endoscopic lesions and healing. We compared the effectiveness of omeprazole 20 mg and 40 mg daily, misoprostol 200 micr...

Background and aims: Factors predisposing to endoscopic ulcer formation or healing with non-steroidal anti-inflammatory drugs (NSAIDs) have not been well defined. Methods: We used multivariate analysis of data from three large similar trials to identify factors associated with endoscopic lesions and healing. We compared the effectiveness of omeprazole 20 mg and 40 mg daily, misoprostol 200 μg f...

OBJECTIVE To determine whether patients developing ulcers had previously been identified as being at high risk of ulceration using the Scottish Care Information-Diabetes Collaboration (SCI-DC) ulcer risk score and whether the risk score predicts ulcer healing. RESEARCH DESIGN AND METHODS All patients attending the diabetes foot clinic with an ulcer had been assessed for foot ulcer risk using ...

Gastric ulcer healing is a complex process that is regulated by several promoting factors including COX-2 and iNOS. Diabetes mellitus is usually associated with delayed gastric ulcer healing. Hence, the current study was designed to investigate the effect of sitagliptin (dipeptidyl peptidase-4 inhibitor) on gastric ulcer healing and expression of iNOS and COX-2 in rat stomach.The study was cond...

Objective: To examine how aspirin affects the healing of gastric ulcer and angiogenesis. Hematopoietic progenitor cells expressing vascular endothelial growth factor receptor-1 (VEGFR1) promote angiogenesis. We examined the involvement of progenitor cells during the process of ulcer healing. Methods: Gastric ulcers were induced by the serosal application of 100% acetic acid in mice treated with...

Takahashi, Satoru, Takuya Fujita, and Akira Yamamoto. Role of nuclear factor-kB in gastric ulcer healing in rats. Am J Physiol Gastrointest Liver Physiol 280: G1296–G1304, 2001.—We investigated the role of nuclear factor-kB (NF-kB) in gastric ulcer healing in rats. NF-kB was activated in ulcerated tissue but not in normal mucosa, and the level of the activation was decreased with ulcer healing....

AIMS To systematically review the efficacy on ulcer healing of 1-week combination of a proton pump inhibitor plus two antibiotics and to perform a meta-analysis of randomized clinical trials to evaluate whether 7 days of proton pump inhibitor-based triple therapy is sufficient to heal peptic ulcer. METHODS Studies where 1-week proton pump inhibitor-based triple therapy was administered to hea...

Tobacco smoking delays healing of gastric ulcer and may influence duodenal ulceration. Seventy men, all cigarette smokers, were found to have duodenal ulceration at endoscopy. All were advised to stop smoking and received a three-month course of cimetidine. Endoscopy was repeated at three months (n = 63) and at six months (n = 56). At three months most (79%) patients showed ulcer healing and th...