Background: Behcet’s disease (Silk Road disease), a rare immune-mediated multisystem inflammatory disorder described by intermittent oralaphthae and genital ulcer, backsliding uveitis, mucocutaneous, articular, gastrointestinal, neurological vascular manifestations, with no cure.It is brought about changes in the: a) arteries that flexibly blood to the body tissues b) veins return lungs, rear o...

Leprosy presenting with vascular involvement is very rare or probably under-reported. Arteriographic and histopathological analysis has shown in few individuals leprosy previously. It also been found that abnormality central to the pathogenesis of trophic ulcer nerve damage itself. A 37-year-old male presented our center pain, bluish discoloration recurrent ulceration digits hands feet twelve m...

BACKGROUND Chronic planter ulcer, also known as trophic ulcer, shows no tendency towards healing. It is usually seen in sensory deficient foot. The clinical result of a sensory, motor or autonomic loss of a nerve function is frequently the same--ulceration, although the exact cause may vary. The treatment principle involves dressing and avoiding pressure on the ulcerated site called 'offloading...

Nerve growth factor (NGF) is the firstly discovered and best characterized neurotrophic factor, known to play a critical protective role in the development and survival of sympathetic, sensory and forebrain cholinergic neurons. NGF promotes neuritis outgrowth both in vivo and in vitro and nerve cell recovery after ischemic, surgical or chemical injuries. Recently, the therapeutic property of NG...

Between 1957 and 1969 700 patients with duodenal ulceration were treated by selective vagotomy and simple drainage using the electrical stimulation test to achieve complete nerve section. Ten of these patients have been re-admitted to the hospital with further ulceration, one with a lesser curve gastric ulcer and nine with recurrent duodenal disease. The first patient had gastric retention and ...

Neurotrophic keratitis (also called neurotrophic keratopathy) (NTK) is a degenerative disease of the cornea, accompanied with neurogenic inflammation. It caused by sensitive innervation loss trigeminal nerve and characterized reduced sensitivity cornea retardation its healing process. NTC-causing damage to can occur at different levels-from nucleus terminals located in be ocular systemic diseas...

Abstract Aims To prospectively explore the association between sedentary time (SED-time) and development of diabetic foot ulcer (DFU) in people with peripheral neuropathy (DPN). Methods 175 DPN individuals who attended annual evaluation for SAMBA Study (2012–2019) were included. Main outcome measure was first diagnosis DFU. SED-time measured by PAS 2.1 questionnaire. Nerve function evaluated ne...

The influence of the vagal nerve on the inhibitory effect of neurotensin on pentagastrin stimulated gastric acid secretion was investigated in seven duodenal ulcer patients before and after parietal cell vagotomy without drainage. Preoperatively, neurotensin inhibited gastric acid secretion, whereas no effect was found postoperatively. Plasma concentration of neurotensin was identical pre-and p...

Mr. Maingot has collected together the contributions from the pen of 29 front ranking British surgeons and each has written on his own specialty. The subjects include the most recent advances in the surgical fields such as congenital heart disease, vagal resection, retropubic prostatectomy, nerve suture, hypospadias, Parkinson's disease, etc., as well as those not so recent such as intestinal o...

Trigeminal trophic syndrome is an uncommon cause of facial ulcers, that affects the sensitive area of the trigeminal nerve. We present the case of an 84-year-old patient with ulcerated facial trigeminal trophic syndrome, and report the development of a clinico-dermoscopic approach for his clinical examination. The value of this model for the diagnosis of facial ulcers suspected to be a rodent u...