Background & Aims: Losartan is a non-peptide potent antihypertensive agent that acts through blocking angiotensin II receptors. Hyzaar® is a combination product that contains two drugs, losartan and hydrochlorothiazide, used to lower high blood pressure. There are some reports regarding simultaneous measurement of the drugs in pharmaceutical and biological samples which includes HPLC, CE, CEC, ...

' Several perplexing questions involving standardization techniques surface when ultraviolet spectrophotometry is used for the determination of unknown ribonucleic acids isolated from tissue sources. One must consider the effect of hydrolysis on total absorbance, nucleotide makeup of a ribonucleic acid versus molar absorptivity and additivity of riucleotides on total measured absorbance. Experi...

In order to provide a basis for later study of the reaction of a protein to specific chemical alterations in the living cell, an investigation of the dynamics of the transaminase system was begun by attempting to develop a method of proved reliability, lending itself to rapid observation and a high degree of precision, As such a method has not been available for this system, we wish to report t...

Closed form expressions for the high harmonic generation (HHG) conversion efficiency are obtained for the plateau and cutoff regions. The presented formulas eliminate most of the computational complexity related to HHG simulations, and enable a detailed scaling analysis of HHG efficiency as a function of drive laser parameters and material properties. Moreover, in the total absence of any fitti...

A pinhole camera, an extreme ultraviolet (EUV) spectrometer, a fast gatable multichannel plate EUV detector, and a digital camera have been installed on the ASML EUV laboratory setup to perform time-resolved pinhole imaging and EUV spectroscopy on a copy of the Philips EUV hollow cathode discharge plasma source. The main properties of the setup have been characterized. Time-resolved measurement...

Recent studies suggest that ultraviolet-B radiation, a major component of global climate change, can affect the community structure, biomass and functioning of terrestrial microorganisms. In this report, these studies are reviewed and gaps in our understanding highlighted so that future research can provide more conclusive evidence on the mechanisms and wider ecological implications of the impa...

Ultraviolet-B radiation (UV-B, 280-320 nm) has important effects in urban areas, including those on human health. Broadband UV-B radiation is monitored in Baltimore, MD, as part of the Baltimore Ecosystem Study, a long-term ecological research program. We compare broadband UV-B irradiance in Baltimore with UV-B at two nearby locations: a more rural station 64 km southeast and a suburban station...

We present ultrafast photoemission measurements of isolated nanoparticles in vacuum using extreme ultraviolet (EUV) light produced through high harmonic generation. Surface-selective static EUV photoemission measurements were performed on nanoparticles with a wide array of compositions, ranging from ionic crystals to nanodroplets of organic material. We find that the total photoelectron yield v...

A silicon photodiode coated with an interface-engineered Mo/Si multilayer was developed as a polarization sensitive detector. The Mo/B4C/Si multilayer was designed to reflect 13.5-nm extreme-ultraviolet (EUV) radiation at an incident angle of 45 degrees, at which the maximum polarization sensitivity occurs. The sensitivity of this specially coated photodiode and its polarization responses were ...