The various soluble liver protein-carcinogen conjugates produced in vivo by two hepatocarcinogens have been resolved and analyzed according to molecular size. In addition, the molecular sizes of the principal soluble conjugates of three types of carcinogens have been compared in order to deduce whether they originate from a common or similar target pro tein. Adult male rats were fed the liver c...

Many attempts have been made to trace the path by which carcinogens are metabolized, with the hope that this may shed some light on the mecha nism of carcinogenesis. Current literature still con tains conflicting evidence on the question of whether the hydrocarbon itself, perhaps in a pro tein complex, or a metabolite is the active carcino genic agent. The work of Peacock et al. (7) sug gests t...

By targeting the AlP binding conserved domain in three AlP binding cassette superfamily proteins (P-glycoprotein, multidrug resistance pro tein, and cystic fibrosis transmembrane regulator), we isolated the cDNA of a new AlP binding cassette superfamily that was specifically enhanced in a cisplatin-resistant human head and neck cancer KB cell line. A human clone homologous to rat cnnalicular mu...

A complementary DNA (564 base pairs) encoding for the mature region of the growth hormone (GH) of yellowfin porgy Acanthopagrus latus was amplified by polymerase chain reaction. This resultant DNA fragment , ypmGH cDNA, was inserted into baculovirus expression vectors, pAc7 , under the control of the polyhedrin promoter. A 22 kDa pro tein, similar to that of authentic GH , was expressed intrace...

291 The Effects of Ferrous Ion and Dithioerythritol on Inhibition by Hydroxyurea of Ribonucleotide Re ductase. 349 Influence of Estrogens and Endocrine Ablation on Duration of Remission Produced by Ovariectomy or Androgen Treatment of 7,12-Dimethylbenz[a@ anthra cene-induced Rat Mammary Tumors. 353 Inhibitory Effect of D-Glucosamine and Other Sugar Analogs on the Viability and Transplantability...

The aim of this study was to investigate whether gestational diabetes mellitus (GDM) is associated with inflammation by comparing serum levels of human chitinase-3-like pro- tein 1 (YKL-40), neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR). This case control study included 29 pregnant women with GDM and 29 pregnant women with normal glucose tolerance matched for age (± 2 ye...

By targeting the AlP binding conserved domain in three AlP binding cassette superfamily proteins (P-glycoprotein, multidrug resistance pro tein, and cystic fibrosis transmembrane regulator), we isolated the cDNA of a new AlP binding cassette superfamily that was specifically enhanced in a cisplatin-resistant human head and neck cancer KB cell line. A human clone homologous to rat cnnalicular mu...

In recent years, graph clustering methods have rapidly emerged to mine latent knowledge and functions in networks. Most sub-graphs extracting methods that have been introduced fall into graph clustering. In this paper, a novel trend of relevant sub-graphs extraction problem was considered as multi-objective optimization. Genetic Algorithms (GAs) and Simulated Annealing (SA) were then used to so...

The proteins and azoproteins of liver nuclei isolated in aque ous or nonaqueous medium from livers of rats fed the hepato carcinogen 3'-methyl-4-dimethylaminoazobenzene for 20 days were compared. The two types of nuclear preparation ap parently contained similar quantities of saline-soluble and-insoluble protein-bound azo dyes. in aqueous nuclei, the pro tein-bound dyes represent only 3% of tho...

Green fluorescent protein (GFP) is a 27 kD protein consisting of 238 amino acid residues [1]. GFP was first identified in the aquatic jellyfish Aequorea victoria by Osamu Shimomura et al. in 1961 while studying aequorin, a Ca2+-activated photoprotein.Aequorin and GFP are local‐ ized in the light organs of A. victoria and GFP was accidentally discovered when the energy of the blue light emitted ...