BACKGROUND The optimal duration of anticoagulation for a first episode of unprovoked venous thromboembolism (VTE) is uncertain. Methods for predicting risk for recurrence may identify low-risk patients who are less likely to benefit from prolonged anticoagulation. PURPOSE To synthesize evidence evaluating the value of D-dimer as a predictor of recurrent disease in patients who have stopped an...

We tested the association between a biomarker of early sex differentiation, the second-to-fourth finger length ratio (2D:4D), and unprovoked attack during a simulated war game (n = 176). We also investigated whether 2D:4D mediated the tendency for men to attack more than women and whether personality dimensions previously associated with sex differences in aggression or hostility (social domina...

Venous thromboembolism (VTE) is a frequent, multifactorial and potentially life-threatening disease [1–3]. When VTE occurs in the absence of any major risk factor (i.e. surgery, prolonged immobilisation or trauma of the lower limb), the risk of recurrent VTE is high (i.e. about 10% at 1 year and 30% at 5 years) after anticoagulation therapy is stopped, and current guidelines recommended indefin...

The use of exogenous oestrogen in women with otherwise unprovoked venous thromboembolism (VTE) could be considered sufficient explanation to classify VTE as provoked if the risk of recurrent VTE after 3-6 months of anticoagulant treatment is similar to the risk of recurrent VTE observed after a surgery or prolonged immobilisation. Our objective was to assess the risk of recurrent VTE in women a...

OBJECTIVE The metabolic syndrome (MetS) may contribute to the pathogenesis of venous thromboembolism (VTE), but this association requires additional investigation. APPROACH AND RESULTS We performed a patient-level meta-analysis of case-control and cohort studies that evaluated the role of MetS and risk of unprovoked VTE. For case-control studies, odds ratios and 95% confidence intervals were ...

BACKGROUND Unprovoked venous thromboembolism (VTE) is related to a higher incidence of occult cancer. D-dimer is clinically used for screening VTE, and has often been shown to be present in patients with malignancy. We explored the predictive value of D-dimer for detecting occult cancer in patients with unprovoked VTE. METHODS We retrospectively examined data from 824 patients diagnosed with ...

Introduction Single unprovoked seizures occur in about 4% of the population and they have significant psychosocial consequences for the patients and their families. Little information is available on the timeliness and safety of assessment of first unprovoked seizures. In this study, we review the timeliness of the referral and evaluation of patients with first unprovoked seizure in a Canadian ...

BACKGROUND Transient symptoms in Alzheimer disease (AD) are frequent and include seizures, syncope, and episodes of inattention or confusion. The incidence of seizures in AD and predictors of which patients with AD might be more predisposed to them is based primarily on retrospective studies and is not well established. OBJECTIVE To determine the incidence and predictors of new-onset unprovok...

Corresponding Author: A.Tavassoli MD Ali-Asghar Children’s Hospital,Tehran, Iran Emial: [email protected] Abstract Objective The first attack of unprovoked seizure is more frequent than recurrent one and neuroimaging is one of the main parts of the evaluation of these attacks in order to demonstrate the cause and predict the prognosis. The aim of this study was to determine the incidence...

It takes about 3 months to complete "active treatment" of venous thromboembolism (VTE), with further treatment serving to prevent new episodes of thrombosis ("pure secondary prevention"). Consequently, VTE should generally be treated for either 3 months or indefinitely (exceptions will be described in the text). The decision to stop anticoagulants at 3 months or to treat indefinitely is dominat...