Copyright © 2007 Massachusetts Medical Society. Medical progress has altered the course and thus the definition of uremia, which once encompassed all the signs and symptoms of advanced kidney failure. Hypertension due to volume overload, hypocalcemic tetany, and anemia due to erythropoietin deficiency were once considered signs of uremia but were removed from this category as their causes were ...

Inflammatory cytokines are evoked by acute kidney injury (AKI) and may contribute to evolving renal disease. However, the impact of AKI-induced uremia on proinflammatory (e.g., TNF-alpha, MCP-1, TGF-beta1) and anti-inflammatory (e.g., IL-10) cytokine gene expression remains unknown. This study was undertaken to gain some initial insights into this issue. CD-1 mice were subjected to left renal i...

investigates complaints incoming to the medical council of west azarbaijan province during 1385 to 1389     hemmati maslakpak m [1] , baghaie r [2] , yosefi m [3] ,ghavami h [4] *     received: 9 dec , 2012 accepted: 18 feb , 2013     abstract:   background & aims : increased complaints from the medical team and medical staff, and increased risk of therapeutic measures in recent years, was the ...

Posterior reversible encephalopathy syndrome (PRES) is characterized by acute onset of headache, nausea, focal neurological deficits or seizures along with radiological findings of white matter defects in the parietal and occipital lobes. Causes of PRES include uremia, hypertensive encephalopathy, eclampsia and immunosuppressive medications. Usually, the treatment of choice involves correcting ...

BACKGROUND Uremia-associated immune deficiency is a well-known complication of loss of renal function and contributes significantly to the overall mortality and morbidity of patients with end-stage renal disease. Chronic inflammation and increased oxidative stress are underlying the uremia-associated immune deficiency. SUMMARY In this review, the differential impact of uremia on the cellular ...

OBJECTIVE End-stage renal failure has profound changes in human gene expressions, but the molecular causation of these pleomorphic effects termed uremia is poorly understood. The purpose of this study was to explore key genes in uremia by comparing classification performance of five kinds of significant genes based on the support vector machines (SVM) model. MATERIALS AND METHODS The five kin...

The pathogenesis of cachexia in patients with uremia is unknown. We tested the hypothesis that uremia-associated cachexia is caused by leptin signaling through the hypothalamic melanocortin receptor 4 (MC4-R). We performed either subtotal nephrectomy (N) or sham operations in WT, leptin receptor-deficient (db/db), and MC4-R knockout (MC4-RKO) mice. The animals were on 17% protein diets, and non...

Data on 16 patients with uremia are presented. The cerebral blood flow was moderately decreased in patients with generalized vascular disease, but was normal in patients with minimal vascular involvement. In both groups the cerebral oxygen consumption (cerebral metabolic rate in terms of oxygen consumption, CAIRO,) was reduced significantly and to the same degree. In contrast, total body metabo...