Exposure to loud sounds is a common cause and exacerbater of tinnitus - a troubling auditory symptom that affects millions of people worldwide. Clinical research at the National Center for Rehabilitative Auditory Research has resulted in a clinical model of tinnitus management referred to as Progressive Audiologic Tinnitus Management (PATM). The model involves five hierarchical levels of manage...

SUMMARY Applications of nanotechnology to medicine are leading to novel means of imaging living systems and of delivering therapy. Much nanotechnology research is focused on methods for imaging central nervous system functions and disease states. In this review, the principles of nanoparticle design and function are discussed with specific emphasis on applications to neuroradiology. In addition...

We review novel technologies with diagnostic and therapeutic applications in dermatology. Among the diagnostic techniques that promise to become part of dermatologic practice in the future are optical coherence tomography, multiphoton laser scanning microscopy, Raman spectroscopy, thermography, and 7-T magnetic resonance imaging. Advances in therapy include novel light-based treatments, such as...

Antibiotic resistance, a global concern, is particularly pressing in developing nations, including India, where the burden of infectious disease is high and healthcare spending is low. The Global Antibiotic Resistance Partnership (GARP) was established to develop actionable policy recommendations specifically relevant to low- and middle-income countries where suboptimal access to antibiotics - ...

Although the therapeutic uses of tumor necrosis factor alpha antagonists have added a highly effective treatment of ankylosing spondylitis and associated spondyloarthropathies, they are associated with many untoward effects. We describe a Saudi patient with ankylosing spondylitis who developed severe psoriatic lesions in treatment with infliximab. He had no personal, or family history of psoria...

As part of the research project, an extended literature review was undertaken to distinguish the relationship between hepcidin, the iron regulatory protein, and its role in the progression of carcinogenesis, based on regulation and expression in iron abundant cells. The review also aims to critically assess hepcidin’s role in iron metabolism and the link between iron overload/ deficiency disord...

The fourth article in this 5-part series reviews physical modalities and devices used to treat cutaneous rosacea based on consensus recommendations from the American Acne & Rosacea Society (AARS) on the management of the common presentations of cutaneous rosacea. The major therapeutic uses of physical modalities and devices, especially laser and light-based systems, are for treatment of telangi...

In the present era of targeted therapy, monoclonal antibodies (mAb) are result of the idea of a “magic bullet” which was first proposed by Paul Ehrlich, who, at the beginning of the 20th century, postulated that, if a compound could be made that selectively targeted a disease-causing organism, then a toxin for that organism could be delivered along with the agent of selectivity. Monoclonal anti...

Aims: Although the increasing importance of traditional medicinal system (jamu) in Indonesia, there are no studies regarding the perceptions of the clients with respect to the risk of consuming jamu products. The paper addresses this gap by examining the perceptions of jamu and risk of consuming traditional medicine among the consumers of the city of Yogyakarta, Indonesia. Methodology: Sixty in...

Organs that metabolize the drug: Liver: 60%. Mediated in a polymorphic way by the P450 2D6 enzyme, producing inactive metabolites and meta-O-delkylateflecainide with a 20% activity of the drug. Patients with poor CYP2D6-mediated metabolism (heterozygous -EMs and intermediate and poor metabolizers) showed agerelated reduction in flecainide metabolism because metabolism was taken over by CYP1A2, ...