Silica supported phosphorus pentoxide (P2O5·SiO2) is an efficient catalyst for synthesis of 1,3,5-substituted pyrazoles via the condensation of 1,3-diketones and hydrazines. Simplicity of procedure, mild condition, being solvent-free, high yields, and easy workup are some advantages of this protocol.

Pyrazoles are an important class of five membered heterocyclic compounds; are widely found as the core structure in a large variety of compounds that possess important agrochemical and pharmaceutical activities. Pyrazoles have been the recent target of numerous methodologies, mostly due to their prevalence as scaffolds in synthesis of bioactive compounds and reactions in different media. The ai...

Synthesis of di-pyrrolyl-substituted pyrazoles (dpp) and anion binding studies in protonated form are reported. Dpp show [2 + 2] binding of trifluoroacetate in the solid state to afford nanometer- and micrometer-scale architectures.

A highly selective and efficient method for the synthesis of 5-trifluoromethylated and 5-perfluoroalkylated pyrazoles has been developed which relies on the cyclization of hydrazine dianions with ethyl perfluorocarboxylates. The pyrazoles prepared were evaluated as potential inhibitors of alkaline phosphatases, namely human tissue non-specific alkaline phosphatase (h-TNAP) and tissue specific i...

Pyrazoles have potential applications in the agrochemical and medicinal chemistry industries as pesticides, anti-inflammatory medications, antitumor drugs. Fluorinated fused-ring pyrazoles may also possess medicinally useful properties. Herein, we report acid-catalyzed synthesis of a new tricyclic, trifluoromethylated indenopyrazole, 3-methyl-1-(4-(trifluoromethyl)phenyl)indeno[1,2-c]pyrazol-4(...

silica supported phosphorus pentoxide (p2o5·sio2) is an efficient catalyst for synthesis of 1,3,5-substituted pyrazoles via the condensation of 1,3-diketones and hydrazines. simplicity of procedure, mild condition, being solvent-free, high yields, and easy workup are some advantages of this protocol.

BACKGROUND Most of the known approaches to the synthesis of CF3-containing organic compounds suffer from serious drawbacks. For example the starting materials required for these methods are rather difficult to obtain, or they are fairly toxic and inconvenient to work with and methods for direct fluorination and trifluoromethylation do not always allow the introduction of the CF3-group at the re...

The development of a mild, general, and green method for the C-H arylation pyrazoles with relatively unreactive aryl halides is an ongoing challenge in organic synthesis. We describe herein novel sonophotoreactor based on ultrasonic cleaning bath blue LED light (visible light) that induce copper-catalyzed monoarylation pharmacologically relevant pyrazoles. hybrid effect irradiation discussed to...

Background: Pyrazole is a simple aromatic ring an organic compound of the heterocyclic series that characterized five-membered ring structure which comprises located adjacent two nitrogen atoms and three carbon atoms. In recent years interest in the pyrazole chemistry excessively has increased due to many a wide range of properties. Because they have a wide range of specific properties such as ...

Objective: Pyrazoles have wide application in medicinal chemistry because of diverse pharmacological activities. As a part of our ongoing research to identify potential inhibitors of cysteine proteases, these observations were guiding initiatives in the present work for the synthesis of some pyrazoles with a desire to see their inhibitory effect on endogenous proteolysis. Methods: We have synth...