We report the isolation and amino acid sequences of six novel dimeric disintegrins from the venoms of Vipera lebetina obtusa (VLO), V. berus (VB), V. ammodytes (VA), Echis ocellatus (EO) and Echis multisquamatus (EMS). Disintegrins VLO4, VB7, VA6 and EO4 displayed the RGD motif and inhibited the adhesion of K562 cells, expressing the integrin alpha5beta1 to immobilized fibronectin. A second gro...

abstract background and objective: snake venom is a complex of several toxic elements and enzymes. it has the agents with the ability to destroy cellular and subcellular membrane and to bring about hemolysis of red blood cells (rbc). two types of direct and indirect hemolytic activity are known in snake venom in that phospholipase a2 is responsible for the indirect lysis. the aim of this study ...

background snake venom is a complex mixture of different components including proteins and peptides that mostly has enzymatic properties. in this study, the alkaline phosphatase (alp) activity is measured in iranian vipera lebetina, venomous snake on sephadex g-100 to investigate the suitability of this procedure. material and methods the method of this study is experimental. 100 mg of the crud...