OBJECTIVE To estimate the efficacy and safety of low-dose oral misoprostol compared with dinoprostone (PGE2), vaginal misoprostol, and oxytocin for labor induction in women with a viable fetus. DATA SOURCES We conducted electronic database searches of PubMed, MEDLINE, EMBASE, and the Cochrane Library for articles published before January 2008 using the keywords misoprostol, labor, induction, ...

Introduction: This study was conducted to evaluate the efficacy of 800µg vaginal misoprostol after wetting alkaline PH vagina with 3% acetic acid in comparison with 800µg vaginal misoprostol alone in the alkaline PH vagina in terminating first trimester pregnancies. Methods: In this clinical trial, a total of 100 healthy women between 20 and 40 years old requesting legal terminat...

introduction: the purpose of this study was to compare the efficacy and side effects of two different misoprostol regimens for second-trimester pregnancy termination. methods: 60 consenting women who were at 14 to 28 weeks of gestation with indications for pregnancy termination were randomly assigned to two equal groups to receive either vaginal or oral misoprostol. the dosing regimen was 400µg...

BACKGROUND Sublingual and vaginal routes of misoprostol have been found to be effective for pharmacological ripening prior to surgical termination of first trimester abortions. We conducted this study to compare the effectiveness and acceptability of sublingual versus vaginal route of misoprostol for cervical priming prior to vacuum aspiration (VA). METHODS In this prospective clinical trial,...

we want to compare the efficacy and safety of vaginal versus sublingual misoprostol for cervical ripening and induction of labor. this randomized clinical trial was performed on 140 women with medical or obstetric indications for labor induction. the patients were randomly divided into two groups: vaginal and sublingual administration of misoprostol. in first group, 25 µg misoprostol was placed...

BACKGROUND The pharmacokinetics of vaginal misoprostol as a dry tablet or as a tablet moistened with normal saline or with acetic acid were studied. METHODS For this study, 42 women requesting termination of pregnancy at gestational age of <12 weeks were recruited and received 400 µg vaginal misoprostol tablets. They were randomized into three groups: (i) dry tablets, (ii) tablets moistened w...

AIMS to compare the benefits and harms of misoprostol to induce labour in the second and third trimester of pregnancy with cervagem. METHODS MEDLINE was searched using the terms abortion, induced; abortifacient agents; pregnancy, second trimester; pregnancy, third trimester; misoprostol; cervagem; and gemeprost to identify randomised controlled trials in which misoprostol was compared with ce...

We want to compare the efficacy and safety of vaginal versus sublingual misoprostol for cervical ripening and induction of labor. This randomized clinical trial was performed on 140 women with medical or obstetric indications for labor induction. The patients were randomly divided into two groups: vaginal and sublingual administration of misoprostol. In first group, 25 µg misoprostol was placed...

Objective: To compare the efficacy of misoprostol 50 μg vaginally and 50 μg sublingually for labor induction at term. Materials and Methods: One hundred and twenty women were randomized to receive misoprostol 50 μg vaginally (n = 60) or 50 μg sublingually misoprostol (n = 60). The doses were g iven every 5 h (maximum 5 doses). Primary outcome measure was vaginal delivery rate. Induction to deli...

The objective of this prospective randomized placebo-controlled study was to determine the effectiveness of 400 mug oral and 400 mug vaginal misoprostol administration for cervical priming 3 h prior to manual vacuum aspiration (MVA) under local anesthesia for voluntary termination of pregnancy before 10 weeks of gestation in comparison with placebo oral or placebo vaginal administration (n=40 i...