objective(s): herbal medicines are promising cancer preventive candidates. it has been shown that punica granatum l. could inhibit angiogenesis and tumor invasion. in this study, we investigated whether the anti-angiogenic effect of pomegranate peel extract (ppe) is partly attributable to peroxisome proliferator-activated receptors (ppars) activation in the human umbilical vein endothelial cell...

purpose : to review the effectiveness and safety of perioperative injection of bevacizumab in vitrectomy for proliferative diabetic retinopathy (pdr) methods : a literature search of all english articles from the medline and scopus databases was performed. original articles, case reports and letters were included. results : nineteen, 3 and 5 studies reported preoperative, intraoperative and pos...

the role of angiogenic molecules, like vascular endothelial growth factor (vegf) and fibroblast growth factor (fgf) in tumor angiogenesis was well confirmed. photodynamic therapy (pdt) action is, to very high degree, based on tumor vasculature damage. therefore, it seemed to be important to evaluate growth factor receptors after pdt. the extent of receptor expression was studied by immuno-histo...

background :chronic obstructive pulmonary disease (copd) is a third leading cause of death.   methods : in this case control study, we prepared 5 cc bloods from the antecubital vein of 100 copd patients and 40 healthy individuals as control group. vascular endothelial growth factor (vegf) expression protein level was measured by elisa in both groups.   results : we found that concentration of v...

Background and Objective: Vascular endothelial growth factor (VEGF) is a cytokine which is overexpressed in many malignant cancers including leukemia. VEGF plays an important role in tumor invasion and metastasis. Determination of the pattern of VEGF expression in human leukemic cell lines could be useful not only in screening of new antileukemic agents but also to study the mechanism of their ...

objective(s): the aim of this study is to determine the effects of progesterone treatment on the survival of random skin flaps. materials and methods: mcfarlane flaps were established and 40 male rats were randomly assigned to the progesterone-treated as the test group or normal saline-treated as the control group. progesterone or normal saline (10 mg/kg) was administered intraperitoneally once...

background: beta-adrenergic blocking agents have been broadly used for treatment of many cardiovascular diseases such as arterial hypertension and ischemic heart failure. anti-tumoral, anti-inflammatory and anti-angiogenesis effects of propranolol (a non-selective beta-adrenergic blocker) have been shown. angiogenesis (replenish of the pre-existing vascular networks) plays a critical role in so...

background: we investigated coronary angiogenesis and serum vascular endothelial growth factor (vegf) and its soluble receptor-1 (sflt-1) concentrations in two-kidney one-clip (2k1c) hypertensive rats before and after reversal of hypertension. methods: the animal groups were: (i) sham-clipped for 12 weeks; (ii) 2k1c for 12 weeks; (iii) sham-clipped for 12 weeks and unclipped for 12 weeks; and (...

we report a case of choroidal neovascularization (cnv) secondary to methylenetetrahydrofolate reductase (mthfr) gene mutation in a 20-year-old male patient with hypopituitarism. treatment with three consecutive injections of intravitreal ranibizumab (anti-vascular endothelial growth factor) resulted in significant improvement of the patient’s vision and the appearance of the macula. a search ...