background: breast cancer is one of the most common cancers in the world, particularly in iran. there are many genomic and molecular factors that cause the occurrence of breast cancer. many markers are associated with tumor invasiveness. matrix metalloproteinase includes a family of zinc-dependent endopeptidases that degrade various components of the extracellular matrix and basement membrane. ...

background and aims. although salivary gland tumors are not very common, early diagnosis and treatment is crucial because of their proximity to vital organs, and therefore, determining the efficacy of new imaging procedures becomes important. this study aimed to evaluate the efficacy of magnetic resonance imaging (mri) and color doppler ultrasonography parameters in the diagnosis and differenti...

Colchicine as a vascular disrupting agent creates microtubule destabilization whichinduces vessel blockage and consequently cell death. Accordingly, colchicines and itsanalogues radiolabeled with 99mTc may have potential for visualization of tumor. In this work,deacetylcolchicine a colchicine analogue was labeled with 99mTc via tricine as a coligandand characterized for its tumor targeting prop...

epithelioid hemangioendothelioma is a vascular tumor with an intermediate malignant potential. this tumor is very rare in the lung parenchyma, and most of the previously reported cases have been asymptomatic. there is no standard therapy for this tumor and prognosis in the previous reports has been variable. herein we report our experience with a 60-year-old woman presenting with hemoptysis and...

Colchicine as a vascular disrupting agent creates microtubule destabilization whichinduces vessel blockage and consequently cell death. Accordingly, colchicines and itsanalogues radiolabeled with 99mTc may have potential for visualization of tumor. In this work,deacetylcolchicine a colchicine analogue was labeled with 99mTc via tricine as a coligandand characterized for its tumor targeting prop...

Background: Tumor microenvironment is an active factor participating in immunoregulation, thereby preventing immunosurveillance and limiting the efficacy of anticancer therapies. Hypoxia as a major characteristic of solid tumors causes the expression of Hypoxia-Inducible Factor-1α (HIF-1α). This is a transcription factor that mediates hypoxic responses of tumor cells and involves in the express...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 vascular neoplasms, other than benign are characterized as intermediate or malignant. they are often enshrouded in controversy, because the same neoplasm could show variability in biologic behavior that may not be correlated with microscopic features. the intermediate grade vascular neoplasm is named as epithelioid hemangi...

  Background and Objectives: Retinoblastoma is the most common intraocular pediatric malignancy. Angiogenic factor expression such as VEGF (vascular endothelial growth factor) in retinoblastoma can be confirmatory angiogenic potential of this tumor. This study was performed to determine the role of angiogenesis in local invasion of retinoblastoma and its correlation with patients’ sur...