OBJECTIVES Morphological changes of blood vessel wall have been described in placenta from pregnancies complicated by diabetes mellitus type-I. STUDY DESIGN We measured mRNA expression of vascular endothelial growth factor (VEGF), angiopoietin 1 and 2 (Ang-1 and Ang-2), their receptors VEGFR-1, VEGFR-2, Tie-2, fibroblast growth factor 2 (FGF-2), and its receptor FGF-2R in placental tissue of ...

BACKGROUND Vascular endothelial growth factor receptor-2 (VEGFR-2) signaling is an obligate requirement for normal development and pathological angiogenesis such as cancer and age-related macular degeneration. Although autophosphorylation of tyrosine 1173 (Y1173) of VEGFR-2 is considered a focal point for its angiogenic signal relay, however, the mechanism of phosphorylation of Y1173, signaling...

Downloa ors induce new blood vessel growth primarily from host organ microvascular endothelial cells (EC), and vasculature differs significantly between the lung and liver. Vascular endothelial growth factor (VEGF GF-A) promotion of tumor angiogenesis is thought to be mediated primarily by VEGF receptor-2 R-2). In this study, VEGFR-2 antibody (DC101) inhibited growth of RenCa renal cell carcino...

UNLABELLED Lung cancer accounts for 17% of cancer-related deaths worldwide, and most patients present with locally advanced or metastatic disease. Novel PET imaging agents for assessing vascular endothelial growth factor receptor-2 (VEGFR-2) expression can be used for detecting VEGFR-2-positive malignancies and subsequent monitoring of therapeutic response to VEGFR-2-targeted therapies. Here, w...

Vascular endothelial growth factor-A (VEGF) signals vascular development and angiogenesis mainly by binding to VEGF receptor family member 2 (VEGFR-2). Adaptor proteins mediate many VEGFR-2's functions in the development of blood vessels. Cancer cells secrete VEGF to activate VEGFR-2 pathway in their neighboring endothelial cells in the process of cancer-related angiogenesis. Interestingly, act...

Glioblastoma multiforme (GBM) is one of the most angiogenic tumors. However, antiangiogenic therapy has not shown significant clinical efficacy. The aim of our study was to evaluate the impact of inflammatory tumor microenvironment on the expression of vascular endothelial growth factor receptor 2 (VEGFR-2). Surgically excised primary GBM tissues were histologically examined for overall extent ...

Downlo ors induce new blood vessel growth primarily from host organ microvascular endothelial cells (EC), and vasculature differs significantly between the lung and liver. Vascular endothelial growth factor (VEGF GF-A) promotion of tumor angiogenesis is thought to be mediated primarily by VEGF receptor-2 R-2). In this study, VEGFR-2 antibody (DC101) inhibited growth of RenCa renal cell carcinom...

Recently, we have reported a series of isatin hydrazone, two them, namely, 3-((2,6-dichlorobenzylidene)hydrazono)indolin-2-one (1) and 3-((2-chloro-6-fluorobenzylidene)hydrazono)indolin-2-one (2) having potent cytotoxicity, showing cyclin-dependent kinases (CDK2) inhibitory activity bearing recommended drug likeness properties. Since both compounds (1 2) showed against CDK2, assumed it would al...