Autophagy is dysfunctional in many degenerative diseases including myopathies. Mutations in valosin-containing protein (VCP) cause inclusion body myopathy (IBM) associated with Paget's disease of the bone, fronto-temporal dementia and amyotrophic lateral sclerosis (IBMPFD/ALS). VCP is necessary for protein degradation via the proteasome and lysosome. IBMPFD/ALS mutations in VCP disrupt autophag...

p97/VCP, a member of the AAA-ATPase super family, has been associated with a wide variety of essential cellular protein pathways com prising: (i) nuclear envelope reconstruction, (ii) cell cycle, (iii) Golgi reassembly, (iv) suppression of apoptosis and (v) DNA-damage response [1-6]. In addition, vasolin-containing protein (VCP) dislodges the ubiquitinated proteins from the endoplasmic reticulu...

Aims and objectives: Vocal cord palsy (VCP) can be definitely depicted on computed tomograpy (CT) scan by identifying key points at the level of true vocal cords and aryepiglottic folds. There are various VCP mimics and imaging shortcomings, and these can usually be circumvented by thoughtfully assessing the scan plan and level, and a diligent search for additional characteristics. Materials an...

OBJECTIVES Anti-citrullinated protein/peptide antibodies (ACPA), a family of antibodies with overlapping specificities, represent a specific marker of rheumatoid arthritis (RA). The aim of the present study is to investigate the prevalence and clinical significance of IgG, IgA and IgM ACPA by a newly described assay employing a viral citrullinated peptide (VCP). METHODS IgG, IgA and IgM anti-...

The measurement of the mutual impedance of thin circular loop antennas on an N-layered conducting medium at high frequency is calculated. The horizontal, vertical coplanar, perpendicular and vertical coaxial loop antennas have been presented, the comparison between them and the numerical results have been calculated. The displacement currents in free space and in the conducting medium are taken...

Abnormal protein aggregates are commonly observed in affected neurons in many neurodegenerative disorders. We have reported that VCP (valosin-containing protein) co-localizes with protein aggregates in neurons of patients and in cultured cells expressing diseased proteins. However, the significance of such co-localization remains to be elucidated. In the present paper, I discuss the involvement...

PURPOSE Valosin-containing protein (VCP or p97) is associated with antiapoptotic function and metastasis via activation of the nuclear factor-kappaB signaling pathway. The present study was designed to investigate the prognostic significance of VCP expression in colorectal adenocarcinoma. EXPERIMENTAL DESIGN We analyzed VCP expression immunohistochemically in 129 patients with colorectal carc...

In 3 experiments, we examined maneuver choice, flight safety, and mental workload across 3-dimensional (3D) perspective and 2-dimensional coplanar cockpit displays of traffic information in a free-flight simulation. In Experiment 1 (30 pilots), we examined dimensionality issues; in Experiments 2 and 3 (18 pilots each), we examined the effects of traffic density, dimensionality, and vertical pro...

The paper presents the design of a novel ultra-wideband microwave crossover for the use in microstrip circuits. The proposed structure includes a double microstrip-coplanar waveguide (CPW) vertical interconnect in single-layer substrate technology which allows an inclusion of a finite-width coplanar waveguide (CPW) on the top side of the substrate to achieve the required cross-link. The present...

BACKGROUND Vocal cord paralysis (VCP) is one of the postoperative complications after radical esophagectomy. VCP may also lead to serious morbidities such as respiratory distress and aspiration pneumonia. Therefore, an early diagnosis of VCP is meaningful in the postoperative management of patients undergoing esophagectomy. We evaluated a new practical method for diagnosing postoperative VCP. ...