Our visual system has many interesting abilities like vestibulo-ocular reflex. These abilities are helpful for us to perceive the environment effectively and often have adaptability to the environment. On the other way, LSSI (Local Sensory Signals Integration) learning base on the smoothness of the relation between the spatial and temporal information, has been already proposed. In this paper, ...

KEY POINTS Directionality, inherent to movements, has behavioural and neuronal correlates. Direction of vestibular stimulation determines motor learning efficiency. Vestibulo-ocular reflex gain-increase correlates with Purkinje cell simple spike potentiation. The locus of neural correlates for vestibulo-ocular reflex adaptation is paradigm specific. ABSTRACT Compensatory eye movements elicite...

The performance of the smooth pursuit reflex and the ability to suppress the vestibulo-ocular reflex were assessed in 10 normal subjects and in patients with a variety of diseases of the central nervous system. Pursuit was measured as the maximum velocity of slow phase eye movement in response to a laser target moving sinusoidally at various frequencies up to 1 Hz and with amplitudes stepped up...

Cerebellar long-term depression (LTD) is a model system for neuronal information storage that has an absolute requirement for activation of protein kinase C (PKC). It has been claimed to underlie several forms of cerebellar motor learning. Previous studies using various knockout mice (mGluR1, GluRdelta2, glial fibrillary acidic protein) have supported this claim; however, this work has suffered...

Humans are able to stabilize the images of moving targets on the retina by means of smooth pursuit eye movements. After the pontine level, all smooth pursuit pathways pass through the cerebellum. Previous animal studies gave evidence that two specific lesion sites within the cerebellum cause smooth pursuit disorders: those of the flocculus/paraflocculus and the vermis including lobule VI, VII, ...

This study aimed to examine the vestibulo-collic reflex (VCR) and linear vestibulo-ocular (lVOR) their correlation with brain lesions in pediatric-onset multiple sclerosis (POMS). The group consisted of 17 patients (34 ears) POMS (mean age 18.73 ± 2.02, mean at disease onset 14.64 1.36 years), control included 11 age-matched healthy subjects (22 ears). Ocular cervical Vestibular Evoked Myogenic...

Eye movement abnormalities consisting of poor or absent smooth pursuit and vestibulo-ocular reflex suppression, gaze-paretic and rebound nystagmus, slow build-up of optokinetic nystagmus, mildly hyperactive vestibulo-ocular reflex, and a high incidence of strabismus were inherited in an autosomal dominant fashion in 10 members of a non-consanguineous English caucasian family. The onset was in e...