We evaluated the Abbott RealTime (ART) and Roche Cobas TaqMan Hepatitis C virus (HCV) viral load assays for quantification of HCV genotypes in patient specimens. The ART HCV assay was a more sensitive and precise tool for accurate HCV viral load quantification across the HCV genotypes tested, especially genotype 1b.

In the United Kingdom, the National Screening Programme for identification of hepatitits B virus (HBV) infection in pregnant women uses HBV e antigen (HBeAg) and antibody to HBeAg (anti-HBe) as markers of infectivity to determine use of immunoglobulin for hepatitis B. Serum samples from 114 HBV-infected women were analyzed. Viral loads correlated with HBeAg/anti-HBe status and viral genotypes. ...

abstract: genotyping of the hepatitis c virus (hcv) is important for designing therapeutic strategies and regional specific diagnostic assays. the aim of this study was to identify the hcv genotypes in hcv infected blood donors. this is the first report on hcv genotypes in blood donors in iran. in this cross-sectional study, 103 blood donors with hepatitis c were investigated for hcv genotypes....

conclusions our findings showed that hcv infection could lead to increased expression level of tlr7 mrna in peripheral blood cells of hcv infected samples. the viral load and genotypes of hcv did not affect the mrna expression levels of tlr2 and tlr7. background hepatitis c virus (hcv) is an important human pathogen affecting an estimated 120 – 170 million individuals in the world. toll-like re...

Hepatitis C virus (HCV) infection causes acute and chronic hepatitis leading to cirrhosis and hepatocellular carcinoma which are the major health problems around the world including Thai population. Many recent studies were shown an important role of microRNA (miRNA) to inhibit or promote viral replication. This study aimed to investigate human miRNAs and analyze hybridization patterns between ...

OBJECTIVE Hepatitis C virus (HCV) has emerged as a leading cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma worldwide. The purpose of this study was to describe the distribution pattern of HCV genotypes in chronic hepatitis patients in the Campania region of southern Italy and estimate their association with risk factors and viral load. MATERIALS AND METHODS 404 consec...

today, chronic viral hepatitis is considered as a public health problem in the world. totally, 5% of the world population, especially in asia and africa suffer from this problem. the prevalence of acute hepatitis in america is 0.1-0.2 percent, 50% of those with hepatitis c (hcv) and 5-10% of them with hepatitis b (hcv) develop chronic hepatitis. determining hbv and hcv genotypes is important to...

PURPOSE IL28B genotypes have a strong impact on treatment outcomes of chronic hepatitis C (CHC) and on-treatment viral kinetics. Since metabolic regulation and interferon response are highly integrated, metabolic profiles may play an important role in the link between IL28B genotypes and hepatitis C virus (HCV) infection. Thus, the association of IL28B rs8099917 genotypes with metabolic profile...

In the 1970s and 1980s, serological tests developed for hepatitis A and B viruses (HAV, HBV) indicated that most transfusion-associated hepatitis was not caused by either HAV or HBV, and were therefore named non-A, non-B hepatitis (NANBH). After detection of the first NANBH-specific clone, the entire viral genome of the now termed hepatitis C virus (HCV) was sequenced, and based on its structur...

The clinical impact of viral factors (types and viral loads) during respiratory syncytial virus (RSV) infection is still controversial, especially regarding newly described genotypes. In this study, infants with RSV bronchiolitis were recruited to describe the association of these viral factors with severity of infection. RSV antigenic types, genotypes, and viral loads were determined from hosp...