background and aims: the caspases are unique proteases that mediate the host cell apoptosis during viral infection. in this study, we identified the caspase cleavage motifs of h5n1 and h9n2 influenza viruses isolated during 1998-2012. materials and methods: amino acid sequences of the eleven proteins encoded by the viruses as the caspase substrates downloaded from ncbi. the caspase cleavage mot...

the ds-rna activated protein kinase (pkr) is a serine-threonine kinase with mw of 68 kda. it belongs to a family of kinases that control one of the translational initiation factors, eif2. pkr is produced at high level in response to viral infection. this protein by phosphorylating eif2 inhibits cellular protein synthesis. in this study, the effect of gamma interferon (ifn-γ), an activator, and ...

viral hepatitis, as an international public health concern, seriously affects communities and health system. in recent years, great strides have been taken for development of new potential tools against viral hepatitis. among these efforts, a valuable strategy introduced new molecules called “aptamers”. aptamers as potential alternatives for antibodies could be directed against any protein in i...

abstract background and aims: the number of new cancer cases with considerable mortality is increasing worldwide. since the inability of current therapies in treatment of patients and prevention the progress of tumors with fewer side effects, implementation of new methods is needed. gene therapy has widespread systemic cytotoxic effects against tumor cells. rotavirus nsp4 has been shown to elic...

To develop such a system, a retrospective study was performed on patients with meningitis admitted at three major pediatric hospitals during a ten-year period. In this study, important cerebrospinal fluid ( CSF) indices were measured and compared in cases of bacterial and viral meningitis. Glucose, protein and white blood cells (WBCs) were analyzed in 609 patients with meningitis and scores wer...

COVID-19 pandemic defined a worldwide health crisis into humanitarian crisis. Amid this global emergency, human civilization is under enormous strain since no proper therapeutic method discovered yet. A wave of research effort has been put toward the invention therapeutics and vaccines against COVID-19. Contrarily, spread fatal virus already infected millions people claimed many lives all over ...

Objective: Influenza virus, which is associated with high level of morbidity and mortality, has been recently considered a public health concern; however, the methods of choice to control and treat it are limited. Our previous study showed anti-influenza virus activity of pomegranate peel extract (PPE). In this study, the mechanism through which PPE acts against influenza virus...