Adrenocortical carcinoma (ACC) is a malignant tumour arising from the adrenal cortex, while pheochromocytoma is a catecholamine secreting tumour of the adrenal medulla or extra adrenal sites. Both conditions are very rare, with incidence of approximately 1-2 cases per million adults annually. Most adrenocortical tumours are functioning. ACC can be associated with clinical Cushing syndrome and v...

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Background. Our knowledge on long-term outcome in CAH remains incomplete. Methods. In a prospective study (33 CAH patients, 33 age-matched controls), reproductive outcomes, self-rating of genital appearance and function, and sexuality were correlated to degree of initial virilisation, genotype, and surgery. Results. Patients had larger median clitoral lengths (10.0 mm [range 2-30] versus 3.5 [2...

This report describes the case of a 28 year old woman with virilisation occurring in two successive pregnancies. Recurrent maternal virilisation is rare (seven previous reports) and this case is unique in its severity. Differential diagnoses include ovarian disease and fetal aromatase deficiency. New techniques to exclude a fetal cause were used in this case. This patient presented during the t...

AIM To analyse critically a protocol for the investigation of girls presenting with virilisation in childhood. METHODS Twenty five girls aged 1.6-8.7 years with features of virilisation were evaluated. Twenty four had presented with pubic hair, eight with auxilliary hair, seven with facial acne, four with clitoromegaly, and 10 with tall stature. They underwent clinical assessment (height, wei...

Letters an unusual case of localised hypertrichosis editor Topical testosterone is now a widely used mode of testosterone replacement therapy. It is well reported that transcutaneous absorption of testosterone may lead to hirsuitism and virilisation. 1,2 We report an interesting case of localised hypertrichosis on the forearm of a female patient and postulate that this was the result of acciden...

Letters an unusual case of localised hypertrichosis editor Topical testosterone is now a widely used mode of testosterone replacement therapy. It is well reported that transcutaneous absorption of testosterone may lead to hirsuitism and virilisation. 1,2 We report an interesting case of localised hypertrichosis on the forearm of a female patient and postulate that this was the result of acciden...