Thiocyanate, a ubiquitous anion in the body, inhibits the concentration of iodide by the thyroid and the iodination of tyrosine in this tissue (1, 2). This pseudohalide is oxidized by thyroid tissue in viva (3-6). Sulfate is the major sulfur product. This report will describe a cytoplasmic particulate system derived from mammalian thyroid tissue that oxidizes thiocyanate ion in vitro to product...