The use of differential reinforcement of other behavior (DRO) has decreased, at least partially due to the development of less effortful alternative behavioral interventions (e.g., noncontingent reinforcement; Vollmer, Iwata, Zarcone, Smith, & Mazaleski, 1993). The effort associated with DRO contingencies may be lessened by incorporating self-monitoring components in which clients are responsib...

Hundreds of organic chemicals are used during natural gas extraction via high-volume hydraulic fracturing (HVHF). However, it is unclear whether these chemicals, injected into deep shale horizons, reach shallow groundwater aquifers and affect local water quality, either from those deep HVHF injection sites or from the surface or shallow subsurface. Here, we report detectable levels of organic c...

Artyku? po?wi?cony jest retorycznym i kulturowym aspektom ekspozycji idei m?dro?ci w Pampaedii Jana Amosa Kome?skiego. Szkic koncentruje si? zw?aszcza na rozpo-znaniu sposobów jej ukazywania oraz ujawniania zaplecza intelektualnego – kontekstów ?róde?, które stale o?ywiaj? my?l Amosa, jak unaocznieniu funkcji miejsca strukturze dzie?a. Badania ujawniaj?, i? „m?dro??” dla Kome?skiego najwa?niejs...

Cannabinoid receptors (CBR) are located on cholinergic neurons in the brain stem, stomach, and colon. CBR stimulation inhibits motility in rodents. Effects in humans are unclear. Dronabinol (DRO), a nonselective CBR agonist, inhibits colonic motility and sensation. The aim of this study was to compare effects of DRO and placebo (PLA) on colonic motility and sensation in healthy volunteers. Fift...

Using a strategy based on nucleotide sequence homology between genes encoding receptors that interact with guanine nucleotide-binding proteins, we have isolated Drosophila genomic and cDNA clones encoding a functional serotonin receptor (5HT-dro receptor). This protein is expressed predominantly in Drosophila heads and exhibits highest homology with the human 5HT1A receptor. The predicted struc...

Vocal stereotypy is a common problem behavior among persons with autism spectrum disorder and can prove to be a fairly difficult behavior to treat. One of the main reasons that this behavior is often challenging is that it is usually maintained by the sensory consequences that it produces. Response interruption and redirection and differential reinforcement of other behavior are two treatments ...

We investigated integrin-linked kinase (ILK), a focal adhesion serine-threonine protein kinase, as a new molecular target for treating anaplastic thyroid cancer. ILK mediates cell growth and survival signals and is overexpressed in a number of cancers. Therefore, we hypothesized that inhibition of ILK leads to growth arrest and apoptosis of thyroid cancer cells. According to Western blotting, t...

The purpose of this study was to compare two methods designed to produce tic reduction in 4 children with Tourette's syndrome. Specifically, a verbal instruction not to engage in tics was compared to a verbal instruction plus differential reinforcement of zero-rate behavior (DRO). Results showed that the DRO-enhanced procedure yielded greater reductions in tic frequency.

We propose a Bayesian framework for assessing the relative strengths of data-driven ambiguity sets in distributionally robust optimization (DRO) when the underlying distribution is defined by a finite-dimensional parameter. The key idea is to measure the relative size between a candidate ambiguity set and a specific asymptotically optimal set. As the amount of data grows large, this asymptotica...