the role of the ventromedial nuclei of the hypothalamus (vmn) in food behavior was studied in adult male rats, allocated in 3 groups: control, sham and lesioned. electrolytic lesions were induced stereotaxically (1.2 ma, 15 sec). results revealed a significant decrease (p

background: there are some reports in the literature showing that hypothalamus synthesizes and secretes amino acid neurotransmitters. according to several studies, elevated serum levels of gamma-amino butyric acid (gaba), a potent inhibitory neurotransmitter, have recently been implicated in the pathogenesis of neural diseases. the purpose of this research was to estimate the effects of curcumi...

Obesity is a chronic disease that shows the most serious global health problems .It relates to the body fat .Obesity is caused by an imbalance between energy intake and expenditure, this balance is regulated by genetic and environmental interactions. Obesity, which is a risk factor for chronic diseases, has become epidemic in the developed countries. Resistance to Leptin hormone is one of the m...

CONTEXT Transport of thyroid hormone across the plasma membrane is required for proper thyroid hormone action and metabolism. Several specific thyroid hormone transporters have been identified capable of facilitating uptake and/or efflux of thyroid hormones. Monocarboxylate transporter (MCT)-8, MCT10, and organic anion transporting polypeptide 1C1 (OATP1C1) are the best-characterized specific t...

Neural stem cells (NSCs) were recently revealed to exist in the hypothalamus of adult mice. Here, following our observation showing that a partial loss of hypothalamic NSCs caused weight gain and glucose intolerance, we studied if NSCs-based cell therapy could be developed to control these disorders. While hypothalamus-implanted NSCs failed to survive in mice with obesity, NF-κB inhibition indu...

As Director of the Office of Scientific Research and Development, Dr. Vannevar Bush has coordinated the activities of some six thousand leading American scientists in the application of science to warfare. In this significant article he holds up an incentive for scientists when the fighting has ceased. He urges that men of science should then turn to the massive task of making more accessible o...

How do experienced users extract information from a complex visualization? We examine this question by presenting experienced weather forecasters with visualizations that did not show the needed information explicitly and examining their eye movements. We replicated Carpenter & Shah (1998) when the information was explicitly available on the visualization. However, when the information was not ...

The importance of socioeconomic position, measured at multiple levels (e.g., individual, household, area) and across the life course, for studying health disparities is now well recognized (1–7). Our multilevel study (8) reported that individual-based socioeconomic measures (IBSMs) and area-based socioeconomic measures (ABSMs) together capture birth weight inequalities that otherwise would have...

gamma aminobutyrate (gaba) is a non-protein amino acid that is thought to play an important role in the modulation of the central response to stress. mechanisms by which gaba may facilitate these responses to stress are metabolic and/or mechanical disruptions. environmental stresses increase gaba accumulation through cytosolic acidification, induce an acidic ph-dependent activation of glutamate...