OBJECTIVE To assess cognitive and behavioral outcome in treated maternal phenylketonuria (PKU) offspring. METHODS In this prospective, longitudinal study, 228 children who were born to mothers with treated PKU or untreated mild hyperphenylalaninemia were compared with 70 control subjects at 7 years of age. RESULTS Offspring cognitive outcome negatively correlated with the number of gestatio...

RESULTSdThe median 6 SD FPG value was 4.58 6 0.437. FPG decreased with increasing gestational age. FPG level at first prenatal visit was strongly correlated with GDM diagnosed at 24–28 gestational weeks (x = 959.3, P, 0.001). The incidences of GDM were 37.0, 52.7, and 66.2%, respectively, for women with FPG at the first prenatal visit between 5.10 and 5.59, 5.60 and 6.09, and 6.10–6.99 mmol/L. ...

The purpose of this study is to compare obstetric and birthweight data of twin children from the two largest databases in Japan to estimate the difference between them in sample collection. The first group consisted of 1131 twin-pair school applicants, and the second group consisted of members' children from several maternal associations devoted to twins and included 951 pairs. All data were ga...

BACKGROUND International comparison and time trend surveillance of preterm delivery rates is complex. New techniques that could facilitate interpretation of such rates are needed. METHODS We studied all live births and stillbirths (>or= 28 weeks gestation) registered in the medical birth registers in Sweden, Denmark and Norway from 1995 through 2004. Gestational age was determined by best est...

BACKGROUND Male-mediated spontaneous abortion is well described among animals, but less well documented in humans. Studies that include early pregnancy experience are expensive to conduct, but IVF provides new opportunities. MATERIALS AND METHODS The Danish IVF register covers all IVF treatments performed after 1993. We mailed a questionnaire to 5879 women (response rate 68.2%). A subgroup of...

OBJECTIVE This study had two aims: (1) to examine pregnant women's alcohol consumption across time from prepregnancy until childbirth and (2) to explore whether prepregnancy drinking and intention to drink predict prenatal alcohol consumption while controlling for relevant demographic variables. METHODS At 17-21 weeks, 248 pregnant women completed questions about demographics, intention to dr...