The nonsense-mediated mRNA decay (NMD) pathway degrades mRNAs containing long 3'UTRs to perform dual roles in mRNA quality control and gene expression regulation. However, expansion of vertebrate 3'UTR functions has required a physical expansion of 3'UTR lengths, complicating the process of detecting nonsense mutations. We show that the polypyrimidine tract binding protein 1 (PTBP1) shields spe...

Issues around research ethics and the reproducibility of research are impacting the credibility of science. Firstly, we look at what is to be understand by research ethics, misconduct, and reproducibility. Next, we examine some examples of fraud, beautification, and failed reproducibility. Next, we address the causes and possible resolutions, culminating in the question whether the scholarly li...

This paper studies inference in a continuous time game where an agent's decision to quit an activity depends on the participation of other players. In equilibrium, similar actions can be explained not only by direct influences but also by correlated factors. Our model can be seen as a simultaneous duration model with multiple decision makers and interdependent durations. We study the problem of...