Hepatic and splenic microsomal electron transport system function, microsomal heme oxygenase activity, and microsomal drug metabolism have been examined in male Wistar rats bearing Murphy-Sturm lymphosarcoma 2 to 15 days following i.m. tumor transplantation. Hepatic microsomal cytochrome P450 and NADPH-cytochrome c reducÃ-ase activity decreased significantly [cytochrome P-450 nadir was 0.49 ± ...

The catabolism <>l5-fluorouracM ill mi »as measured in isolated perfused rat liver (IPRL) at various times of the day. IPRLs were prepared from rats sacrificed at 3-h intervals and the elimination rate of FUra and FUra catabolites (i.e., rate leaving the II'KI in the effluent perfusate) following infusion of |'I l|l I ni »as analy/.ed for circadian periodicity. Animals were housed under stand...

The interval between administration of carcinogen and development of sarcomas was significantly shorter in male Fischer rats that received bilateral injections into thigh muscles of a combination of 10 mg of Ni3S2 and 5 mg of 3,4-benzpyrene (Group C) than in rats that received only 10 mg of Ni3S2 (Group A) or only 5 mg of 3,4-benzpyrene (Group B). No sarcomas developed in control rats (Group D)...

In this paper, we investigate compactly supported symmetric orthonormal dyadic complex wavelets such that the symmetric orthonormal refinable functions have high linear-phase moments and the antisymmetric wavelets have high vanishing moments. Such wavelets naturally lead to real-valued symmetric tight wavelet frames with some desirable moment properties, and are related to coiflets which are re...

This study presents a summary of sixty years air temperature and precipitation measurements at the Žabčice weather station, located in southeastern Czech Republic operated by Mendel University Brno. An instrumental dataset spanning two climatological normal periods (1961- 1990 newly established 1991-2020) is analyzed for long term linear trends with monthly data presented full span Appendices...

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The quantum phase description of Noh, Fougères and Mandel (NFM) leads to a two-mode theory of phase in the strong local oscillator limit. We show that the explicit form of the eigenstates of the sine and the cosine phase operators in two-mode Fock space can be constructed. This brings great convenience to the NFM quantum phase approach. Recently, phase operators and phase measurements in quantu...

Small-cell carcinoma of the lung is a highly lethal form of cancer associated with a wide variety of paraneoplastic syndromes. Using the patch-clamp technique, we have directly demonstrated the presence of voltage-gated k4. Na4, and (a24 channels in three cell lines of human small-cell carcinoma, NCI-HI28, NCI-H69, and NCI-HI46. Whole-cell currents were measured from the tumor cells held at —...

Small-cell carcinoma of the lung is a highly lethal form of cancer associated with a wide variety of paraneoplastic syndromes. Using the patch-clamp technique, we have directly demonstrated the presence of voltage-gated k4. Na4, and (a24 channels in three cell lines of human small-cell carcinoma, NCI-HI28, NCI-H69, and NCI-HI46. Whole-cell currents were measured from the tumor cells held at —...

The years 1895 to 1898 were momentous for their impact on health and human well beings. First, Wilhelm Roentgen noted a glowing fluorescent screen, caused by invisible rays. This event subsequently led to the discovery of X-rays in 1895, and thus the birth of the “atomic age”. Next Becquerel’s investigations of these mysterious rays led to his experiments with uranium salt crystals. He th...