BACKGROUND Matrix metalloproteinases (MMPs) are crucial in the inflammatory and remodeling phases of wound healing. We previously reported the correlation between pro-inflammatory cytokines and timing of successful combat-wound closure. We now extend our studies to investigate the correlation between wound-remodeling MMP expression and wound healing. METHODS Thirty-eight wounds in 25 patients...

BACKGROUND The aim of this study is to evaluate the effects of tourniquet release before wound closure for hemostasis or after wound closure in cemented total knee arthroplasty (TKA). METHODS We conducted a meta-analysis and review work on relevant clinical outcomes to evaluate the effects of the timing of tourniquet release in cemented TKA. Electronic databases were searched for relevant ran...

Radiation-related wounds challenge surgeons in all disciplines of surgery. Wound-healing complications are commonplace, and solutions for reconstruction are limited. Muscle and musculocutaneous flaps have improved this situation. But the question is, does previous radiation of the muscle to be transposed affect the outcome? 143 consecutive previously irradiated patients treated with muscle...

Objective-This study was conducted to evaluate the effect of co-administration of Aloe vera gel and cinnamon zeynalicum bark hydroethanolic extract on process of wound healing in diabetic mice model.Design- Experimental Study.Animals- Seventy-two male BALB/c mice.Procedures- A single full-thickness excisional wound was created on ba...

PURPOSE To compare 2 methods of wound closure-metallic staples or 3-0 undyed vicryl-according to postoperative wound complication rates. METHODS Patients who underwent surgery for proximal femoral fractures were randomised to have wound closure with metallic staples or with subcuticular vicryl suture. Wounds were regularly examined postoperatively and only those with positive wound swabs were...

BACKGROUND Growing evidence in the orthopaedic arthroplasty literature supports the use of running bidirectional barbed suture (barbed suture) for closure of knee arthrotomies. More rapid wound closure and suture line integrity are described as its major advantages. No studies of barbed suture for the closure of posterior spinal wounds exist. The purpose of this project is to compare wound clos...

OBJECTIVE To assess the local wound complications in complicated/ high risk laparotomies in terms of wound dehiscence and incisional hernia formation with a modified technique of midline abdominal wound closure. STUDY DESIGN Quasi-experimental study. PLACE AND DURATION OF STUDY Department of General Surgery, Combined Military Hospital, Bahawal Nagar Cantonment, May 2006 to June 2008. METH...

A subcuticular suture is an ideal closure method of surgical wounds where the aim is healing by primary intention. The addition of adhesive strips over the subcuticular suture appears to be based on anecdotal, rather than experimental evidence. We performed a prospective study to compare the postoperative wound complications of combination closure with subcuticular closure alone. The wounds of ...

Background Wound closure is highly associated with wound complications and the best wound closure method was controversial in total hip arthroplasty. Methods We performed a retrospective study of primary hip arthroplasty and compared three types of closure method. Results 155 cases were closed using continuous subcuticular sutures then with staples, 111 using staples, 141 using interrupted ...