Objective(s) The process of wound healing involves tightly integrated events including inflammation, granulation tissue formation and remodeling. Systemic administration of L-arginine promotes wound healing but its global side effects are undesirable. To confine the action of L-arginine at the site of injury, we tested the effects of local administration of L-arginine on the healing of excisio...

Despite decades of research on wound healing, effective biologic agents for the treatment of chronic wounds, especially diabetic wounds, are still lacking. In the present study, we report that the inert plasma protein plasminogen (plg) acts as a key regulatory molecule that potentiates wound healing in mice. Early in the healing process, plg bound to inflammatory cells is transported to the wou...

Surgical wounds in cancer patients have a relatively high dehiscence rate. Although cancer resections are performed so as to include macroscopically non-involved tissues, some cancer cells can be present in the line of transection or surrounding tissues (R1 and R2 resections). The local healing process may facilitate proliferation of these localized cancer cells, and the high cytokine concentra...

OBJECTIVE To observe the promoting effect of arnebia root oils on expression of basic fibroblast growth factor (bFGF) in skin wound of rabbits and the histomorphological changes in the wound surface, and to discuss its mechanism. METHODS Bilateral round skin wounds were made on the back of 15 rabbits. The three wounds on one side of the back of each rabbit were treated with arnebia root oils,...

- healing of surgical wounds and their complications such as infection or scar formation are of major concern in surgery. tissue glues are advanced to reduce these problems. in a prospective study, we have evaluated surgical wound healing in 76 patients whose surgical wounds were repaired by tissue glues (histoacryl). this study was performed in four leaching hospitals (sina, shariaty, shohada,...

Accurate and rapid assessment of the healing status of a wound in a simple and noninvasive manner would enable clinicians to diagnose wounds in real time and promptly adjust treatments to hasten the resolution of nonhealing wounds. Histologic and biochemical characterization of biopsied wound tissue, which is currently the only reliable method for wound assessment, is invasive, complex to inter...

The different types of acute skin wounds, including surgically created wounds, partial thickness injuries, burns, and traumatic wound, involve significant tissue loss and wound healing duration which could take time. Although the wound healing process varies among the different types of wounds, there are more similarities than differences between these healing process (Monaco and Lawrence, 2003...

AIMS This study aimed to evaluate stromal wound healing morphology in short term unsutured compared with sutured corneal wounds, to define regional variation in healing within radial keratotomy wounds. METHODS Stromal scar tissue orientation (fibroblast and collagen fibre orientation) was analysed in unsutured and adjacent sutured keratotomy wounds in monkeys, 2 to 9 weeks after surgery, usin...

Most surgical wounds are categorised as acute wounds, healing without complication in an expected time frame (Bale and Jones, 1997). However, like all wounds, healing is affected by intrinsic and extrinsic factors that may result in complications.

Introduction: Hedera helix is an evergreen plant used in treatment of wounds in the Iranian folk medicine. One of the main stages in wound healing process is, the proliferative phase in which fibroblasts proliferate within the wounds and produce extracellular matrix. Collagen is the main constituent of extracellular matrix. So the aim of this study was to evaluate the effect of Hedera helix alc...