The uses of non-steroidal anti-inflammatory drugs (NSAIDs) are limited by a variety of side effects. So research on preparing new analgesic agents is important. According to some reports about the analgesic activity of hydrazide and hydrazine derivatives a new series of these compounds were synthesized in order to obtain new analgesic compounds. The final compounds 10a-10e and 15a-15d were pre...

(3) first described a syndrome, commonly referred to as "writhing", which was induced in rodents by the intraperitoneal injection of various chemical agents. Collier et al. (4) have recently reported experiments on the abilities of various sub stances, including some occurring in tissues and causing pain in man, to induce abdominal construction in mice. Many investigators have described the non...

A series of phenoxybenzylidene aroylhydrazine derivatives were synthesized and their structureswere confirmed using FT-IR and 1H-NMR spectroscopy. Analgesic profiles of all compoundswere examined using abdominal constriction test (writhing test). Most of synthesized compoundsinduced significant reduction in the writhing response as compared with controls. The mostactive compounds exhibited an a...

The influence of cyclooxygenase (COX) and NO synthase inhibitors on antinociceptive action of acetaminophen (ACETA) was studied in rats. ACETA increased the nociceptive threshold for both mechanical (Randall-Selitto test) and chemical stimuli (writhing test). In both models the existence of ceiling dose of ACETA was observed. Indomethacin (IND), an inhibitor preferentially acting on COX-1, as w...

ETHNOPHARMACOLOGICAL RELEVANCE Leaf extracts of Buddleja globosa (Buddlejaceae) are used in Chilean folk medicine for wound healing. The anti-inflammatory (topic and per os), analgesic (per os) effects and the antioxidant activity of Buddleja globosa were for the first time reported by us. AIM OF THE STUDY Assess the antinociceptive activity of the methanol sequential and global extracts usin...

objective: premna integrifolia linn (family: verbenaceae) synonym of premna serratifolia has tremendous medicinal value. preliminary pharmacological studies were performed on the methanolic extract of premna integrifolia (mepi) bark to investigate neuropharmacological, analgesic, and anti-inflammatory activities. materials and methods: neuropharmacology study was done by open field and hole cro...

Background 
 Ficus religiosa, commonly known as peepal, is widely distributed in Indian subcontinent. It has been used an antiepileptic, aphrodisiac, analgesic, anti-inflammatory and laxative traditional medicine.
 Objective To explore the analgesic effect of aqueous root extract religiosa using thermal chemical models pain swiss albino mice.
 Method The aerial was prepared soxhl...

BACKGROUND In Iranian traditional medicine, gum obtained from Astragalus gummifer and some other species of Astragalus was used as analgesic agent. OBJECTIVE In this study, we investigated the antinociceptive effect of several concentrations (125, 250, and 500 μg/kg body weight) of Astragalus gummifer gum (AGG) on thermal and acetic acid induced pain in mice. MATERIALS AND METHODS AGG was d...

Croton cordiifolius Baill. is a shrub known as "quebra-faca" and is used to treat inflammation, pain, wounds, and gastrointestinal disturbances in the semiarid region in the northeast of Brazil. In an ethnobotanical survey in the state of Pernambuco, "quebra-faca" use was cited in 33% of the interviews. Thus, we decided to evaluate the antinociceptive effects of the essential oil from C. cordii...