New antimicrobial properties of products derived from Humulus lupulus L. such as antiadherent and antibiofilm activities were evaluated. The growth of gram-positive but not gram-negative bacteria was inhibited to different extents by these compounds. An extract of hop cones containing 51% xanthohumol was slightly less active against S. aureus strains (MIC range 31.2-125.0  μg/mL) than pure xant...

Cholangiocarcinoma remains the second most prevalent hepatic neoplasm in the United States with a 5-year survival rate of less than 10%. Currently, no systemic therapy has demonstrated efficacy. Therefore, an urgent need for the identification of molecularly targeted compound(s) remains. The Notch signaling pathway has been shown to be dysregulated in cholangiocarcinoma, exhibiting hyperactivit...

Xanthohumol is a major prenylated, hydrophobic flavonoid found in the female inflorescences of the hop plant (Humulus lupulus L.). In this study, we examined the effects of xanthohumol-rich hop extract containing 17.8% xanthohumol and 12.4% isoxanthohumol on the differentiation and adipogenesis of 3T3L1 cells. We observed that the extract inhibited the differentiation of 3T3L1 cells and intrace...

K EY WORDS MALDI imaging, drug metabolism, hops flavanoids, xanthohumol, Humulus lupulus L., small molecule drug discovery and development MALDI Imaging of Distribution of Xanthohumol and Its Metabolites in Rat Tissues Henry Shion1; Dejan Nikolic2; Birgit Dietz3; Guido Pauli3; Brian Wright2; Ghenet Hagos2; Daniel Lantvit3; Alan Millar1; John Shockcor1; and Richard van Breemen2 1Waters Corporati...

Obesity contributes to increased risk for several chronic diseases including cardiovascular disease and type 2 diabetes. Xanthohumol, a prenylated flavonoid from hops (Humulus lupulus), was tested for efficacy on biomarkers of metabolic syndrome in 4 week old Zucker fa/fa rats, a rodent model of obesity. Rats received daily oral doses of xanthohumol at 0, 1.86, 5.64, and 16.9 mg/kg BW for 6 wee...

BACKGROUND The detection of molecular targets for flavonoids in cell signalling has opened new perspectives for their application in medicine. Both tangeretin, a citrus methoxyflavone, and xanthohumol, the main prenylated chalcone present in hops (Humulus lupulus L.), act on the mitogen-activated protein kinase pathway and await further investigation for administration in vivo. MATERIALS AND ...

Citation: Huang X, Wang J, Chen X, Liu P, Wang S, Song F, Zhang Z, Zhu F, Huang X, Liu J, Song G, Spencer PS and Yang X (2018) The Prenylflavonoid Xanthohumol Reduces Alzheimer-Like Changes and Modulates Multiple Pathogenic Molecular Pathways in the Neuro2a/APPswe Cell Model of AD. Front. Pharmacol. 9:199. doi: 10.3389/fphar.2018.00199 The Prenylflavonoid Xanthohumol Reduces Alzheimer-Like Chan...

Investigations were started to develop methods for isolating beneficial polyphenols from hops. As a result two new types of extracts were developed. One is mainly consisting of prenylflavonoids (main ingredient is xanthohumol). This product is not soluble in water but in ethanol. The other extract is water soluble and rich in glycosidically bound polyphenols (multifidol, quercetin, kaempferol)....

Nowadays, the world hop industry is faced with one of the biggest crisis in the history. Permanent decrease of hopping rates in the world beer industry during last 20 years caused many problems to hop producers all around the world. It resulted in the huge surpluses of hop stocks between years 2008 and 2010, the ages known as “years of famine” for hop farmers. Th e hop contains some compounds h...