Our previous study demonstrated that 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole (YC-1) might activate the soluble guanylate cyclase (sGC)/cGMP/protein kinase G (PKG) pathway to induce cyclooxygenase-2 (COX-2) expression in human pulmonary epithelial cells (A549). In this study, we further investigated the role of Raf-1 in YC-1-induced nuclear factor-kappaB (NF-kappaB) activation and COX-2 e...

Oral cancer is a serious and fatal disease. Cisplatin is the first line of chemotherapeutic agent for oral cancer therapy. However, the development of drug resistance and severe side effects cause tremendous problems clinically. In this study, we investigated the pharmacologic mechanisms of YC-1 on cisplatin-resistant human oral cancer cell line, CAR. Our results indicated that YC-1 induced a c...

DENEV, S. A., Tz. PEEVA, P. RADULOVA, P. STANCHEVA, G. STAYKOVA, G. BEEV, P. TODOROVA and S. TCHOBANOVA, 2007. Yeast cultures in ruminant nutrition. Bulg. J. Agric. Sci. 13: 357-374 Interest in the use of fungal direct-fed microbials in ruminant nutrition is considerable. The ban of antibiotic growth promoters in feed for production of animal foods has increased interest in evaluating the effec...

Background: YC-1 (3-(5'-hydroxymethyl-2'furyl)-1-benzyl-indazole) is an allosteric activator of soluble guanylyl cyclase (sGC) and a vasodilator. This study describes a paradox action of YC-1 in isolated vessels of coronary artery disease (CAD) patients which appears to trigger an endothelium-dependent vasoconstrictor pathway present in vessels with endothelial dysfunction. Methods: Effects of ...

1. One of the main problems in the field of multifunctional proteins such as ligandin is the possibility that multiple forms and isoproteins may exist. Because liver ligandin [GSH (reduced glutathione) S-transferase B] consists of equal amounts of Ya (22 000 Da) and Yc (25 000 Da) subunits, and testis ligandin, prepared by the standard technique of anion-exchange and molecular-exclusion chromat...

Inhibition of HIF-1a activity provides an important strategy for the treatment of cancer. Recently, 3-(5 0-hydroxymethyl-2 0–furyl)-1benzyl indazole (YC-1) has been identified as an anti-HIF-1a drug in cancer therapy with unclear molecular mechanism. In the present study, we aimed to investigate the effect and mechanism of YC-1 on HIF-1a in a hepatocellular carcinoma cell line under hypoxic con...

We report the 4.04-Mb draft genome sequence of Arthrobacter sp. YC-RL1, an aromatic compound-degrading bacterium. YC-RL1 could degrade a wide range of aromatic compounds, including naphthaline, 1,2,3,4-tetrachlorobenzene, fluorene, 4-nitrophenol, bisphenol A, biphenyl, and p-xylene. The genome sequence of YC-RL1 will promote the investigation of the biodegradation of aromatic compounds.

Two studies were conducted utilizing 270 chickens to evaluate the efficacy of yeast culture (YC) for both broiler and layer ayian types. In the first experiment, three dietary levels (0, 1.25, 2.50 percent) of YC were included in a nutritionally complete ration and fed to 14-day-old broiler chicks for 8 days. Body weight gain, feed consumption (g) and feed efficiency were not influenced by yeas...

Hypoxia has been shown to have a role in the pathogenesis of several forms of liver disease. The aim of the study was to evaluate the mechanisms of HIF-1α inhibitor, YC-1, during bile duct ligation (BDL)-induced liver fibrosis in mice. Liver fibrosis was induced in mice, and YC-1 was then given intraperitoneally (50 mg/kg) once daily following 5 days. Liver injuries mice that were treated with ...

Prostate cancer is the most frequently diagnosed cancer in men and often requires surgery. Use of near infrared (NIR) technologies to perform image-guided surgery may improve accurate delineation of tumor margins. To facilitate preclinical testing of such outcomes, here we developed and characterized a PSMA-targeted small molecule, YC-27. IRDye 800CW was conjugated to YC-27 or an anti-PSMA anti...