Award Number: W81XWH-08-1-0108 TITLE: The role of eIF4E activity in breast cancer PRINCIPAL INVESTIGATOR: Thomas A Hughes CONTRACTING ORGANIZATION: University of Leeds Leeds LS2 9-0000 REPORT DATE: August 2010 TYPE OF REPORT: Annual PREPARED FOR: U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 DISTRIBUTION STATEMENT:  Approved for public release; distribution ...

We examine the state of game theory. Many important questions have been answered, and game theoretic methods are now central to much economic investigation. We suggest areas where further advances are important, and argue that models of learning and of social preferences provide promising routes for improving and widening game theory’s predictive power, while preserving the sucesses of existing...

Financial institutions around theworld expected themillennium date change (Y2K) to cause an aggregate liquidity shortage. Responding to the concern, the Federal Reserve Bank of New York auctioned Y2K options to primary dealers. The options gave the dealers the right to borrow from the Fed at a predetermined interest rate. Using the implied volatilities of Y2K options and the on/off-the-run spre...

Projects can cause organizations to perform in new ways resulting in the generation of knowledge. Project learning occurs when new knowledge is captured, disseminated, and used by the project team. Y2K utility projects were studied with respect to knowledge benefits and management. Projects from developed countries using western technology were found to have knowledge benefits but their organiz...

There are many commercial tools that address various aspects of the Year 2000 problem. None of these tools, however, make any documented use of plan-based techniques for automated concept recovery. This implies a general perception that plan-based techniques is not useful for this problem. This paper argues that this perception is incorrect and these techniques are in fact mature enough to make...

A new method to measure nonlinear dependence between two variables is described using mutual information to analyze the separate linear and nonlinear components of dependence. This technique, which gives an exact value for the proportion of linear dependence, is then compared with another common test for linearity, the Brock, Dechert and Scheinkman (BDS) test. Copyright c © 0000 John Wiley & So...

This paper introduces a new type of intranet – the compliance intranet – and describes its socio-technical shaping. Compliance intranets serve to enforce industry standards, to measure the performance of a company against industry or governmentally established standards, or to establish standards within the organization or within a larger domain. These intranets may be quality management system...

In a survey we found that most developers have experienced duplicated bug reports, however, only few considered them as a serious problem. This contradicts popular wisdom that considers bug duplicates as a serious problem for open source projects. In the survey, developers also pointed out that the additional information provided by duplicates helps to resolve bugs quicker. In this paper, we th...

The growth of manufacturing was central to the economic development of nineteenth century America. In the early stages of industrialization, the commitment to produce was frequently seasonal or part-time, and establishments might shut down operations for weeks or months at a time. But, as transportation improved and markets widened in their geographic scope and, as technological and organizatio...

The concept of offshoring of professional services first gained attention slightly over 25 years ago. At that time, US companies began to realize the cost-advantage of getting their computer software developed in India and other countries. The concept gained momentum with the advent of Internet and the availability of inexpensive communication technologies. Unrelated events, such as the need to...