Cellularization of the Drosophila embryo results in the formation of a cell monolayer with many characteristics of a polarized epithelium. We have used antibodies specific to cellular junctions and nascent plasma membranes to study the formation of the zonula adherens (ZA) in relation to the establishment of basolateral membrane polarity. The same approach was then used as a test system to iden...

An in vitro method for extraction and quantification of zoledronic acid (ZA) from murine bone was developed. Whole mouse bones were incubated in ZA solutions with predetermined concentrations and bound ZA was subsequently extracted from bone with phosphoric acid and derivatized using trimethylsilyl diazomethane (TMS-DAM). ZA tetra-methyl phosphonate was quantified by liquid chromatography coupl...

PURPOSE A growing body of evidence indicates that zoledronic acid (ZA) can improve the clinical outcome in patients with breast cancer and low estrogen levels. In the present study, we aimed to investigate the survival benefit of ZA administration in postmenopausal Korean women with breast cancer who were also receiving aromatase inhibitors. METHODS Between January 2004 and December 2010, 235...

PURPOSE Intravenous (IV) zoledronic acid (ZA) is commonly used to delay skeletal complications secondary to bone metastases. However, the time associated with ZA administration may represent a significant burden to healthcare providers and patients. This study assessed the time associated with IV ZA infusion in patients with bone metastases secondary to breast or prostate cancer (BC or PC) in t...

The bisphosphonate zoledronic acid (ZA) significantly reduces complications of bone metastasis by inhibiting resident macrophages, the osteoclasts. Recent clinical trials indicate additional anti-metastatic effects of ZA outside the bone. However, which step of metastasis is influenced and whether thisis due to directtoxicity on cancer cells or inhibition of the tumor promoting microenvironment...

Previously we showed that repeated vaginal application of a MIV-150/zinc acetate carrageenan (MIV-150/ZA/CG) gel and a zinc acetate carrageenan (ZA/CG) gel significantly protected macaques from vaginal simian human immunodeficiency virus reverse transcriptase (SHIV-RT) infection. Gels were applied either daily for 2 weeks or every other day for 4 weeks, and the animals were challenged 4-24 h la...

Reumatizam 2010. 57(2) 1Klinika za reumatske bolesti i rehabilitaciju Referentni centar MZSS RH za reumatoidni artritis Klinički bolnički centar Zagreb Kišpatićeva 12 10000 Zagreb 2Klinika za reumatologiju, fi zikalnu medicinu i rehabilitaciju Referentni centar MZSS RH za spondiloartropatije Klinička bolnica “Sestre milosrdnice” Vinogradska 29 10000 Zagreb SPONZORIRANO PRIOPĆENJE SPONSORED COMM...

Outbred Wistar rats were immunised with a single intraperitoneal injection of a mixture of 30 mg of A1(OH)3 and 100microng of gonococcal zeolite antigen (ZA). Ten days after immunisation, ZA prepared from T1 and T4 colonies of Neisseria gonorrhoeae strain GC6 (GC6-T1 ZA and GC6-T4 ZA) were able to elicit a reaginic (IgE) response which declined to low levels by 35 days. There was a significant ...

U novom veku francuski i nemački vojni sanitet razvijaju se paralelno, međusobno koriste iskustva i naizmenično uzimaju primat u razvoju. Francuska u vreme Luja XIV ima najjaču državu, najveću vojsku i najbolji vojni sanitet. Pred kraj XVIII veka iscrpljenost ratovima i zastoj u razvoju države i vojske dovode i do zastoja u razvoju francuskog saniteta, ali u isto vreme Fridrih Veliki uzdiže pru...