Meriones shawi (M.shawi) is the main reservoir host for zoonotic cutaneous leishmaniasis (ZCL) in Central Tunisia. The incorporation of environmental and climatic effects on spread ZCL M. remains difficult. This study presents an agent-based model (ABM) to overcome these difficulties examine impact environment (i.e. vegetation cover) climate temperature) movement prevalence. simulation consider...

Patients who recover from leishmaniasis usually show development of strong immunity and induction of interferon-γ (IFN-γ) and delayed type hypersensitivity. In a randomized trial, we analyzed the IFN-γ response by using a Quantiferon-Leishmania assay against three Leishmania peptide antigens and compared it with results of the leishmanin skin test (LST) in persons residing in areas in Iran to w...

BACKGROUND Zoonotic cutaneous leishmaniasis (ZCL) is a serious and increasing public health problem in many rural areas of Iran. Previous studies showed that rodent control operations are effective in destroying rodents and reducing the incidence of ZCL on a small scale and in special circumstances. The objective of this study was to determine suitable timing for rodent control operations in re...

BACKGROUND Great gerbils, Rhombomys opimus, are the main reservoir host of zoonootic cutaneous leishmaniasis (ZCL) in Iran and neighboring countries. Based on morphological traits two subspecies R. opimus sodalis and R. opimus sargadensis have reported in the country. However, variation in infection rate and signs to Leishmania parasites, phenotype, size, and sexual polymorphisms demand more de...

BACKGROUND & OBJECTIVES In the well-known zoonotic cutaneous leishmaniasis (ZCL) focus in Turkmen Sahara, border of Iran and Turkmenistan, ZCL has increased among humans in the past five years. The present study was undertaken to incriminate vectors of ZCL in the region, and to find molecular variation in Leishmania parasites. METHODS The sandflies were sampled using CDC light-traps and stick...

Following an epidemiological survey of zoonotic cutaneous leishmaniasis (ZCL) in several villages of Badrood, a rural district north of the city of Natanz, central Iran, Phlebotomus (Phlebotomus) papatasi Scopoli were found to be naturally infected with Leishmania (Leishmania) major zymodeme MON-26. Sand flies were collected and dissected biweekly from rodent burrows from May to October 2001. L...

The Zein-2 component named Zc 1 corresponds to a storage protein of an apparent M.W. of 16 kDa present in maize endosperm (1). A comparison of amino acid sequences between this protein and Zc2 (glutelin-2) shows that Zcl corresponds to a truncated Zc2 protein (2). In our laboratory we have isolated and sequenced a genomic clone (pZ3) of 3864 nucleotides coding for Zcl protein. This genomic frag...

BACKGROUND Cutaneous leishmaniasis (CL) remains a serious public health concern in Kerman Province, eastern Iran. This study was aimed to conduct a comprehensive review and highlights various aspects of CL in the province of Kerman. METHODS This article mainly focuses on the studies published in the past 26 years on CL in the province. Current data for the present status were obtained through...

In Morocco, as in most countries around the Mediterranean, leishmaniasis is an important public health problem. The situation has become worrying since the 1970’s and continues to be more complicated. The objective of this work was to realize a historical overview of the classification, evolution, and dispersion of Leishmania parasites and Sandflies in Morocco. The status of the different leish...