In mammals, aldosterone is produced in the zona glomerulosa (zG), the outermost layer of the adrenal cortex, whereas glucocorticoids are produced in adjacent zona fasciculata (zF). However, the cellular mechanisms controlling the zonal development and the differential hormone production (i.e. functional zonation) are poorly understood. To explore the mechanisms, we defined zone-specific transcr...

Aldosterone, which plays a central role in the regulation of blood pressure, is produced by zona glomerulosa (ZG) cells of the adrenal gland. When dysregulated, aldosterone is pathogenic and contributes to the development and progression of cardiovascular and renal disease. Although sustained production of aldosterone requires persistent Ca2+ entr...

We study the computational complexity of approximately counting the number of independent sets of a graph with maximum degree Δ. More generally, for an input graph G = (V,E) and an activity λ > 0, we are interested in the quantity ZG(λ) defined as the sum over independent sets I weighted as w(I) = λ|I|. In statistical physics, ZG(λ) is the partition function for the hard-core model, which is an...

OBJECTIVES To evaluate the bond strength of dental resin agent to zirconia ceramic after surface pre-treatment with different techniques. METHODS Specimens of hot isostatic pressed yttrium-oxide-partially-stabilized zirconia blocks (ZF) were fabricated (Procera Zircon, Nobel Biocare, Sweden) and compared to glossy dense zirconia blocks (ZG). Four groups of specimens with different surface tre...

Let G denote the projective special linear group PSL(2, q), for a prime power q. It is shown that a finite 2-subgroup of the group V(ZG) of augmentation 1 units in the integral group ring ZG of G is isomorphic to a subgroup of G. Furthermore, it is shown that a composition factor of a finite subgroup of V(ZG) is isomorphic to a subgroup of G.

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Rat adrenal cortex comprises three zones of steroidogenic tissues: glomerulosa (ZG), fasciculata (ZF) and reticularis (ZR). The ZG synthesizes mineralocorticoid (aldosterone) in response to low Na+ or high K+ in circulation. In parallel, the ZF and ZR synthesize glucocorticoid (corticosterone) responding to stimulation by the pituitary hormone ACTH. Prolonged ACTHstimulation of rats induces tra...

Noc2, a putative Rab effector, contributes to secretory-granule exocytosis in neuroendocrine and exocrine cells. Here, using two-photon excitation live-cell imaging, we investigated its role in Ca(2+)-dependent zymogen granule (ZG) exocytosis in pancreatic acinar cells from wild-type (WT) and Noc2-knockout (KO) mice. Imaging of a KO acinar cell revealed an expanded granular area, indicating ZG ...

For a torsion unit u of the integral group ring ZG of a finite group G, and a prime p which does not divide the order of u (but the order of G), a relation between the partial augmentations of u on the p-regular classes of G and Brauer character values is noted, analogous to the obvious relation between partial augmentations and ordinary character values. For non-solvable G, consequences concer...

Zona glomerulosa (ZG) cells cultured on plastic within few days dedifferentiate losing their capacity to secrete aldosterone (ALDO) in appreciable amounts. Evidence indicates that extracellular matrix modulates the secretory behavior of adrenocortical cells cultured in vitro. Hence, we compared the morphology and function of rat ZG cells grown on plastic and Matrigel basement membrane matrix (h...