Zinc supplementation has proven beneficial in the treatment of acute child diarrhea and appears to enhance linear growth. There is a theoretical risk of anemia in zinc-supplemented children due to inhibited iron transport via decreased copper absorption. Although many zinc supplementation trials have included hematological measures, the potential effect of zinc on these outcomes has not been qu...

UNLABELLED Alcoholic steatosis is a fundamental metabolic disorder in the progression of alcoholic liver disease. Zinc deficiency is one of the most consistently observed biochemical/nutritional manifestations of alcoholic liver disease. The purpose of this study is to determine whether dietary zinc supplementation to mice previously exposed to alcohol could reverse alcoholic steatosis. Male 12...

objective: major depression is a mood disorder that causes changes in physical activity, appetite, sleep and weight. regarding the role of zinc in the pathology of depression, the present study was aimed to investigate the effects of zinc supplementation in the treatment of this disease. methods: this study was a double-blind randomized clinical trial. forty four patients with major depression ...

BACKGROUND The efficacy of preventive zinc supplementation against diarrhea and respiratory illness may depend on simultaneous supplementation with other micronutrients. We aimed to assess the effect of supplementation with zinc and multiple micronutrients on diarrhea and other causes of non-malarial morbidity. METHODS AND FINDINGS Rural Tanzanian children (n = 612) aged 6-60 months and with ...

BACKGROUND The effect of different ways of zinc supplementation on spatial learning and memory remains unclear. OBJECTIVES This study aims to assess the effectiveness of two ways of zinc supplementation - oral use and intravenous transfusion - in zinc-deficient offspring rats on learning and memory. DESIGN Rats were randomly divided into six groups on the first day of pregnancy (n=12): cont...

BACKGROUND Adjustments in zinc losses and absorption are thought to maintain zinc homeostasis with changes in intake, but the capacity to make these adjustments appears to be affected by aging. Zinc status of the individual may also influence adjustments in fractional zinc absorption. OBJECTIVE The purpose of this study was to compare the effects of changes in zinc status due to zinc suppleme...

BACKGROUND Zinc deficiency is commonly prevalent in children in developing countries and plays a role in decreased immunity and increased risk of infection. Preventive zinc supplementation in healthy children can reduce mortality due to common causes like diarrhea, pneumonia and malaria. The main objective was to determine all-cause mortality and cause-specific mortality and morbidity in childr...

Maternal zinc deficiency during pregnancy has been related to adverse effects on progeny, and there are data showing that mild to moderate zinc deficiency (as assessed by available indicators) is quite common in the developing world. Observational data relating zinc deficiency to adverse fetal outcome have produced conflicting results, mainly because of the lack of a valid indicator of zinc def...

QUESTION Gastroenteritis with diarrhea is a common condition in children, potentially leading to dehydration, morbidity, and in some countries substantial mortality. Is there a role for zinc supplementation in these cases? ANSWER Zinc can be found in a variety of foods, and in Canada some foods are fortified with zinc. Zinc supplementation was shown to be a safe and effective measure to short...

Assessment of zinc status remains a challenge largely because serum/plasma zinc may not accurately reflect an individual's zinc status. The comet assay, a sensitive method capable of detecting intracellular DNA strand breaks, may serve as a functional biomarker of zinc status. We hypothesized that effects of zinc supplementation on intracellular DNA damage could be assessed from samples collect...