The ZRT1 gene encodes the transporter responsible for high affinity zinc uptake in yeast. ZRT1 is transcribed in zinc-limited cells and its transcription is repressed in zinc-replete cells. In this report, we describe a second, post-translational mechanism that regulates ZRT1 activity. In zinc-limited cells, ZRT1 is a stable, N-glycosylated plasma membrane protein. Exposure to high levels of ex...

Much remains to be understood about systemic regulation of zinc uptake in vertebrates, and adequate zinc status is far from always achieved in animals or human. In addition to absorbing zinc from the diet, fish are able to take up zinc directly from the water with the gills. This provides an elegant system to study zinc uptake, how it relates to zinc status, and the expression of genes for prot...

Much remains to be understood about systemic regulation of zinc uptake in vertebrates, and adequate zinc status is far from always achieved in animals or human. In addition to absorbing zinc from the diet, fish are able to take up zinc directly from the water with the gills. This provides an elegant system to study zinc uptake, how it relates to zinc status, and the expression of genes for prot...

Zinc uptake is critical for cell proliferation. On the basis of the evidence that brain tumors are positively-imaged with 65Zn, cellular zinc uptake was studied under growth arrest and apoptosis to understand the relationship between cellular viability and zinc uptake. When NIH3T3 cells were cultured in albumin-coated dishes under the presence of serum, the viability of the cells detached from ...

Zinc resistance in Pseudomonas sp. strain UDG26 was inducible. Induction led to enhanced uptake of the metal. A zinc-sensitive variant (UDG86) took up significantly less metal ion than the resistant one did. The affinity of uninduced and sensitive cells to zinc was less than that of resistant, induced cells. Metal accumulation by induced cells was not inhibited by azide, while 2,4-dinitrophenol...

plant growth promoting rhizobacteria and arbuscular mycorrhizal fungi can inhanced plant growth by increasing nutrient uptake. in order to investigate the effect of pgpr and amf on some morphological parameters, macro (nitrogen, phosphorus, potassium, calcium and magnesium) and micro (iron, zinc and copper) nutrients uptake, percentage of root colonization and some morphological factors of pepp...

Zinc is essential micronutrients for proteins production in plants; also zinc is main composition of ribosome and is essential for their development. Zinc is active element in biochemical processes and has a chemical and biological interaction with some other elements. Phosphorus is the most important element which interferes on zinc uptake by plants. Phosphorus is the important element that in...

Epithelial cells of the small intestine are the site of zinc absorption. Intestinal uptake of zinc is inversely proportional to the dietary supply of this essential micronutrient. The mechanism responsible for this adaptive differential in apical zinc transport is not known. The zinc transporter Zip4 (Slc39a4) is essential for adequate enteric zinc uptake. In mice, Zip4 expression is upregulate...

In most bacteria, zinc depletion is sensed by Zur, whereas the surplus is sensed by different regulators to achieve zinc homeostasis. Here we present evidence that zinc-bound Zur not only represses genes for zinc acquisition but also induces the zitB gene encoding a zinc exporter in Streptomyces coelicolor, a model actinobacteria. Zinc-dependent gene regulation by Zur occurs in two phases. At s...