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Several human monoclonal antibodies directed to tumor-associated glycolipid antigens have been established, but more than one-half of them react with gangliosides and the others react with neutral glycolipids. We report here the first establishment of a human IgM monoclonal antibody directed to the sulfated glycolipid. This monoclonal antibody, M14-376, did not react with SM<and Sm„ which hav...
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The limited angular resolution of γ–ray telescopes prevents the straight identification of the majority of the sources detected so far. This is particularly true for the low latitude, probably galactic ones, only 10 % of which has been identified. Most of the counterparts are Isolated Neutron Stars, both radio–loud and radio–quiet, characterised by an extremely high value of fX /fopt. The best ...
We optimized the modulation of drug resistance by the irreversible augmentation of cytotoxicity of coincubating vinblastine (VNB) with VP16 and the reversible increase in cytotoxicity of coincubation of verapamil (VPL) with VNB and VP-16. VPL was administered as a loading dose (i.v.) (0.15 mg/kg) and then administered as a constant infusion (0.005 mg/kg) over 6 days. 24 h after verapamil, VNB 2...
We derive an efficient CH-type inequality. Quantum mechanics violates our proposed inequality independent of the detection-efficiency problem. In photonic Bell-type experiments [1], when photon pairs with parallel linear polarizations are emitted, one can consider a Clauser-Horne (CH) inequality [2], at the level of hidden variables, in the form − 1 ≤ Srq,HV (â, b̂, â, b̂, λ) ≤ 0 (1) where Srq,HV...
The Major Determinants of Sustainable Development in Selected Pacific, East and West Asian Countries
Sustainable development is a Controversial concept which has been considered over the three decades. It is comprehensive development and includes all of dimensions as âeconomicââ, âsocialââ and ââenvironmentalââ. In economic objective, it requires substantial economic change that can be brought about by investment and trade. They are effective factors of sustainable developm...
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