Background: Deltamethrin (DM) is a synthetic pyrethroid insecticide that can elicit neurotoxicity, leading to apoptosis. There is accumulating evidence that oleuropein (OE) has anti-apoptotic effect. The purpose of this study was to determine the anti-apoptotic effect of OE pretreatment in the neuronal cells of cerebral cortex. Methods: Rats were randomly divided into four groups each containin...

Dominic Beer was one of the pioneers in the reform of psychiatric intensive care units. In the mid-1990s he and his colleagues Carol Paton and myself realised that the quality of care in the locked wards that remained after the opening up of the mental hospitals in the 1950s was extremely variable and sometimes lamentably poor. We carried out a nationwide survey of existing psychiatric intensiv...

The Dulmage–Mendelsohn decomposition (or the DM-decomposition) gives a unique partition of the vertex set of a bipartite graph reflecting the structure of all the maximum matchings therein. A bipartite graph is said to be DM-irreducible if its DM-decomposition consists of a single component. For connected bipartite graphs, this is equivalent to the condition that every edge is contained in some...

We search for a spectral line produced by a dark matter (DM) particle with the mass in the range 40 keV < MDM < 14 MeV, decaying in the DM halo of the Milky Way, using a high-resolution spectrometer SPI on board of INTEGRAL satellite. To distinguish the DM decay line from numerous instrumental lines, found in the SPI background spectrum, we study the dependence of the intensity of the line sign...

The problem of the regulation of activity of intestinal disaccharidases, especially lactase, has attracted the attention of researchers for many years (6,8); there are still many unresolved questions. This chapter, which deals with the authors' recent experiments with rats, summarizes data concerning (a) the effect of variation of carbohydrate intake on the activity of sucrase and lactase, (b) ...

Many planning methods rely on the use of an immediate reward function as a portable and succinct representation of desired behavior. Rewards are often inferred from demonstrated behavior that is assumed to be near-optimal. We examine a framework, Distance Minimization IRL (DM-IRL), for learning reward functions from scores an expert assigns to possibly sub-optimal demonstrations. By changing th...

Molecular dynamic (MD) simulations have been performed on Tth-MCO, a hyperthermophilic multicopper oxidase from thermus thermophilus HB27, in the apo as well as the holo form, with the aim of exploring the structural dynamic properties common to the two conformational states. According to structural comparison between this enzyme and other MCOs, the substrate in process to electron transfer in ...

We present computational results showing eccentricity growth in the inner portions of a protoplanetary disc. We attribute this to the evolving surface density of the disc. The planet creates a gap, which adjusts the balance between the 3:1 (eccentricity exciting) and 2:1 (eccentricity damping) resonances. The eccentricity of the inner disc can rise as high as 0.3, which is sufficient to cause i...

A simple analytical model for estimating the fraction (Ωgas) of matter in gaseous form within the collapsed dark matter (DM) haloes is presented. The model is developed using (i) the Press-Schechter formalism to estimate the fraction of baryons in DM haloes, and (ii) the observational estimates of the star formation rate at different redshifts. The prediction for Ωgas from the model is in broad...

The observed strong dark-to-luminous matter coupling [1, 2, 3] suggests the existence of a some functional relation between visible and DM sources which leads to biased Einstein equations. We show that such a bias appears in the case when the topological structure of the actual Universe at very large distances does not match properly that of the Friedman space. We introduce a bias operator ρDM ...