A genetically diabetic model, KK-CAy mice which were bred by mating female KK mice (aa, BB, cc) with male KK-CAy mice (Aya, BB, CC) was studied on the usefulness as a tool for a pharmacological assay. Body weights of KK-CAy mice increased more rapidly than those of control mice, KK-C. When the body weights of male KK-CAy mice reached about 30 g 10 weeks after birth, their blood glucose levels i...

STO-609, a selective inhibitor of Ca(2+)/calmodulin-dependent protein kinase kinase (CaM-KK) was synthesized, and its inhibitory properties were investigated both in vitro and in vivo. STO-609 inhibits the activities of recombinant CaM-KK alpha and CaM-KK beta isoforms, with K(i) values of 80 and 15 ng/ml, respectively, and also inhibits their autophosphorylation activities. Comparison of the i...

TAKE HOME MESSAGES: 1. Average milk yield was similar for cows in ADS-ST or KK (91.2 vs. 93.0 lbs/d) pens. 2. 1st lactation heifers in the KK pen tended to produce more milk (83.4 vs. 81.0 lbs/d). 3. The initial investment for the ADS-ST was less ($58,500 vs. $118,067). a. ADS-ST = $234/cow vs. $472/cow for the KK coolers. 4. ADS-ST used less electricity, water and had lower daily costs ($27.30...

We introduce and study the continuous Rokhlin property for actions of compact groups on C*-algebras. An important technical result is a characterization in terms asymptotic retracts. As consequence, we derive strong KK-theoretical obstructions to property. Using these, show that UCT preserved under formation crossed products passage fixed point algebras by such actions, even absence nuclearity....

The purpose of the present study was to assess the protective effects of rhein lysinate (RHL) in a KK/HlJ mouse model of diabetic nephropathy (DN) and to explore its mechanism of action. A total of 4 groups were established: C57BL/J control, the KK/HlJ model and 25 and 50 mg/kg/day RHL-treated KK/HlJ groups. The KK/HlJ mouse model of DN was established by streptozotocin injection, followed by m...

We describe a procedure for finding Kaluza-Klein monopole solutions in deconstructed four and five dimensional supersymmetric gauge theories. In the deconstruction of a four dimensional theory, the KK monopoles are finite-action solutions of the Euclidean equations of motion of the finite lattice spacing theory. The “lattice” KK monopoles can be viewed as constituents of continuum-limit four di...

the aim of this study was to test the genotypes effect of dgat1 gene on breeding value in iranian holstein milk production traits. for this purpose, 103 semen samples of registered bulls were collected and then genotyped for partial region of dgat1 gene. the studied traits were milk yield (my), fat yield (fy), protein yield (py), fat percentage (fp) and protein percentage (pp). first lactation ...

Serial changes in myocardial parameters related to non-insulin-dependent diabetes mellitus were investigated in DDY mice (control), untreated KK mice, and KK mice treated with diltiazem (150 micrograms/kg body weight, KKd1: or 300 micrograms/kg body weight diltiazem, KKd2). The isozyme ratio of lactate dehydrogenase (LDH) [(LDH1+LDH2)/(LDH4+LDH5)] was used as an index of aerobic metabolism of m...