Clarifying the response of plant phenology to drought duration is helpful for accurately interpreting and predicting carbon sinks in ecosystems. Based on different phenological periods dominant species Stipa krylovii monthly, seasonal, semiannual time scale typical steppe Inner Mongolia from 1983 2018, results revealed that (1) start growing season (SOS) was characterized by an advance–delay–ad...

Fusion oncoproteins (FOs) resulting from in-frame chromosomal translocations are associated with many aggressive cancers poor patient outcomes. Several FOs now understood to perform their oncogenic functions within biomolecular condensates formed through liquid-liquid phase separation (LLPS). Two classes of phase-separating have emerged, those that form nuclear and alter chromatin biology, incl...

Induction of PC12 pheochromocytoma cells neuronal differentiation upon treatment with nerve growth factor (NGF) is accompanied by a coupled stimulation of c-fos and c-jun oncogene transcription. We found that induction of c-fos and c-jun proto-oncogene mRNAs levels following the endocrine differentiation of PC12 cells by sodium butyrate is uncoupled. While c-fos mRNA level increased within minu...

Abstract The objective of this work was to evaluate the effects dietary supplementation with fructooligosaccharides (FOS) on performance, hematology, and immunology pacu (Piaractus mesopotamicus) juveniles. A total 0 (control), 2.0, 4.0 g kg-1 probiotic were added fish diets. Fish (49.3±4.3 g) allotted into 12 tanks 60 L, in a completely randomized design (n=4). After days, final weight, weight...

To address the role of c-fos proto-oncogene we constructed a plasmid that allows constitutive expression of RNA complementary to c-fos mRNA, and stably introduced this plasmid into F9 embryonal carcinoma cells. Some F9 clones expressing c-fos antisense RNA had a reduced basal level of c-fos mRNA, and were unable to induce a c-fos mRNA as well as its protein when stimulated with phorbol ester or...

Oxidants cause activation of the AP-1 transcription factor in cardiomyocytes. c-Fos, a component of the AP-1 transcription factor, is transiently induced by H2O2 and the induction is sensitive to the protein synthesis inhibitor cycloheximide. With high percentage gel electrophoresis, multiple c-Fos bands were resolved by Western blot analyses, indicating post-translational modification of newly...

During protein N-glycosylation in mammalian cells, free oligosaccharides (fOS) are generated from lipid-linked oligosaccharides by a pyrophosphatase activity and oligosaccharyltransferase and from misfolded glycoproteins by peptide:N-glycanase in both the ER and cytoplasm. Trafficking machinery comprising oligosaccharide-specific ER and lysosomal transporters, an endo-beta-N-acetyl-glucosaminid...

Although quantitative and qualitative granulocyte defects have been described in myelodysplastic syndromes (MDS), the underlying molecular basis of granulocyte dysfunction in MDS is largely unknown. We recently found that FOS mRNA elevation under translation-inhibiting stimuli was significantly smaller in granulocytes from MDS patients than in healthy individuals. The aim of this study is to cl...