In Bacillus subtilis, maturation of 5S rRNA is catalyzed by an enzyme called RNase M5. We searched for potential mRNA substrates for RNase M5 by gene array technology, based on the premise that most endonucleolytic cleavages have an effect on the stability of RNA and hence on steady-state levels of expression. Only a handful of genes had significantly altered expression in rnmV mutants compared...

M5 is a method developed by Quinlan [10] for inducing trees of linear regression models (model trees). The paper addresses the flexibility and optimality in M5 model tree by proposing two new algorithms, namely M5flex and M5opt. M5flex algorithm brings in domain knowledge by enabling the user to choose split attributes and split values for important nodes in a model tree so that the resulting m...

BACKGROUND Evidence-Based Medicine (EBM) is an important competency for the healthcare professional. Experimental evidence of EBM educational interventions from rigorous research studies is limited. The main objective of this study was to assess EBM learning (knowledge, attitudes and self-reported skills) in undergraduate medical students with a randomized controlled trial. METHODS The educat...

A generalization of Nahm’s equation has been recently conjectured by Basu and Harvey to be the BPS condition describing the bound state of a stack of M2branes ending on an M5-brane. In this note exact solutions are presented for the proposed BPS equation – which is from the point of view of the M2-brane world-volume dynamics – with boundary conditions appropriate for M2-branes stretching betwee...

We study a class of classical solutions of three-dimensional N = 6 superconformal Chern-Simons theory coupled with U(N)×U(N) bi-fundamental matter fields. Especially, time evolutions of fuzzy spheres are discussed for both massless and massive cases. For the massive case, there are a variety of solutions having different behaviors according to the value of the mass. In addition to the time-depe...

We study the central charges of the supersymmetry algebra of branes in backgrounds corresponding to wrapped M5-branes. In the case of M5-branes wrapping a holomorphic 2-cycle in C2, we find this allows for a supersymmetric M5-brane probe which is related to the M2-brane probe which describes the BPS spectra of the corresponding N = 2 worldvolume gauge theory. For the case of M5-branes wrapping ...

BACKGROUND AND OBJECTIVES Spinal morphine promotes adequate pain relief, but is not free from side effects. This study aimed at investigating the effects of different spinal morphine doses. METHODS Five groups of seven rats were studied, 24 h after spinal catheter insertion via cisterna magna under anesthesia with muscular ketamine and xylazine. G1 received 10 microl saline solution; groups G...

It is known that there are normal plane maps M5 with minimum degree 5 such that the minimum degree-sum w(S5) of 5-stars at 5-vertices is arbitrarily large. In 1940, Lebesgue showed that if an M5 has no 4-stars of cyclic type (5, 6, 6, 5) centered at 5-vertices, then w(S5) ≤ 68. We improve this bound of 68 to 55 and give a construction of a (5, 6, 6, 5)-free M5 with w(S5) = 48.

The complete amino acid sequence of a peptic fragment (Pep M5) of the group A streptococcal type 5 M protein, the antiphagocytic cell surface molecule of the bacteria, is described. This fragment, comprising nearly half of the native M molecule, is biologically active in that it has the ability to interact with opsonic antibodies as well as to evoke such an antibody response in rabbits. The seq...

Transbilayer movement, or flip-flop, of lipids across the endoplasmic reticulum (ER) is required for membrane biogenesis, protein glycosylation, and GPI anchoring. Specific ER membrane proteins, flippases, are proposed to facilitate lipid flip-flop, but no ER flippase has been biochemically identified. The glycolipid Glc 3Man 9GlcNAc 2-PP-dolichol is the oligosaccharide donor for protein N-glyc...