اهداف: پژوهش حاضر، تلاش می‌کند با بررسی عوامل کلیدی روند بهره‌وری سازمانی در پیشایندها و پسایندهای اجرای خط‌مشی مدیریت سرمایه انسانی، پیش‌ران‌های بدیل ارتقاء را از میان آنها مشخص نماید.طراحی/ روش‌شناسی/ رویکرد: این پژوهش، آمیخته نوع پژوهش‌های کاربردی است. جامعه آماری بخش کیفی ۱۴ نفر خبرگان علمی اجرایی به‌منظور انجام مصاحبه؛ کمی ۲۷۰ کل ۹0۹ نفری بر اساس فرمول کوکران برای اعتبارسنجی یافته‌های به‌ص...

CD8+ T cells induced by Plasmodium yoelii sporozoites develop into protective memory cells without undergoing changes in interleukin-7 receptor alpha (IL-7Ralpha) expression, differing from the development of memory CD8+ T cells against viruses, which is associated with enhanced IL-7Ralpha expression. This suggests a microbe-dependent diversity in the signals determining the development of memo...

Removal of the mRNA 5' cap is an important step in the regulation of mRNA stability. mRNAs are degraded by at least two distinct exonucleolytic decay pathways, one from the 5' end, and the second from the 3' end. Two major cellular decapping enzymes have been identified, and each primarily functions in one of the two decay pathways. The Dcp2 decapping enzyme utilizes capped mRNA as substrate an...

Testosterone (250 microM), 7-ethoxycoumarin (25 microM), and 1-chloro-2,4-dinitrobenzene (CDNB, 50 microM) were used as substrates to compare phase I and II metabolism in rat precision-cut liver slices and rat hepatocytes. Overall clearance to metabolites was significantly greater in hepatocytes for testosterone (1.9- to 16.9-fold), 7-ethoxycoumarin (O-deethylation, 14.8-fold; glucuronidation, ...