Glaucoma, frequently associated with high IOP (intra-ocular pressure), is a leading cause of blindness, characterized by a loss of retinal ganglion cells and the corresponding optic nerve fibres. In the present study, acutely and transiently elevated IOP, characteristic of acute angle-closure glaucoma in humans, was observed in CLR (calcitonin receptor-like receptor) transgenic mice between 1 a...

Intermedin (IMD) is a recently discovered peptide closely related to adrenomedullin. Its principal physiological activity is its role in the regulation of the cardiovascular system, where it exerts a potent hypotensive effect. In addition, data were recently provided showing that this peptide is able to exert a clearcut pro-angiogenic effect both in vitro and in vivo. IMD acts through the non-s...

Calcitonin gene related peptide (CGRP) has a key role in migraine and recently CGRP receptor antagonists have demonstrated clinical efficacy in the treatment of migraine. However, it remains unclear where the CGRP receptors are located within the CGRP signaling pathway in the human trigeminal system and hence the potential antagonist sites of action remain unknown. Therefore we designed a study...

Virtual Machines provide a runtime execution platform combining bytecode portability with a performance close to native code. An overview of current approaches precedes an insight into Microsoft CLR (Common Language Runtime), comparing it to Sun JVM (Java Virtual Machine) and to a native execution environment (IA 32). A reference is also made to CLR in a Unix platform and to techniques on how C...

Of all the pathogen recognition receptor families, C-type lectin receptor (CLR)-induced intracellular signal cascades are indispensable for the initiation and regulation of antifungal immunity. Ongoing experiments over the last decade have elicited diverse CLR functions and novel regulatory mechanisms of CLR-mediated-signaling pathways. In this review, we highlight novel insights in antifungal ...

Nowadays, the contradiction between strict construction land supply restriction and excessive demand is extremely prominent. Construction reduction (CLR) a policy innovation for economically developed regions designed to solve tight constraints of quota as urban development continues in China, however, it leads lack spatial justice. In this study, we address gap use regulation literature regard...

G protein-coupled receptors (GPCRs) are considered to function primarily at the plasma membrane, where they interact with extracellular ligands and couple to G proteins that transmit intracellular signals. Consequently, therapeutic drugs are designed to target GPCRs at the plasma membrane. Activated GPCRs undergo clathrin-dependent endocytosis. Whether GPCRs in endosomes control pathophysiologi...

This paper deals with the problem of modelling and optimal control coffee leaf rust (CLR) in a plantation. We first formulate analyze mathematical model for propagation CLR impulsive effect, which represents non-production period coffee. Then, is formulated solved as an control, showing how biological strategy can be implemented plantation to reduce damage caused by CLR, therefore increasing pr...

MHC-I-specific receptors play a vital role in NK cell-mediated "missing-self" recognition, which contributes to NK cell activation. In contrast, MHC-independent NK recognition mechanisms are less well characterized. In this study, we investigated the role of NKR-P1B:Clr-b (Klrb1:Clec2d) interactions in determining the outcome of murine hematopoietic cell transplantation in vivo. Using a competi...

The Microsoft .NET Common Language Runtime (CLR) offers support for generic types and methods. We develop a mathematical specification for the generics design through a type system and a model for the semantics of a subset of bytecode instructions with generics. We formalize the type-consistency checks performed for the subset by the CLR bytecode verifier. We then prove that adding support for ...