The analgesic activity of the methanol extract of Phyllanthus lawii (MEPL) was investigated in Swiss albino mice with hot plate and acetic acid induced writhing models. The results suggested that MEPL possess potent analgesic activity. The MEPL produced a significant decrease in mice writhing induced by acetic acid suggesting peripheral analgesic activity and elevated mean basal reaction time i...

Glycyrrhetinic acid (Ia) and fourteen derivatives of glycyrrhetinic acid were examined to estimate the antinociceptive activity (tests on writhing and vascular permeability induced by 0.7% acetic acid) and anti-type IV allergic effects in mice. Among them, three dihemiphthalate compounds (IIf, IIIc, IVc) derived from, deoxoglycyrrhetol (IIa), showed strong inhibition of writhing and dye leakage...

Zomepirac sodium inhibited the reflex hypertension caused by an injection of bradykinin into the splenic artery of anaesthetized dogs, but not that by injection of bradykinin plus PGE1. In the rat acetic acid writhing test, the potency ratio of intraperitoneal (ED50 = 0.41 microgram/kg) to intravenous (ED50 = 33.5 micrograms/kg) anti-writhing activity of zomepirac sodium was 79.2 (37.1-173), th...

The uses of non-steroidal anti-inflammatory drugs (NSAIDs) are limited by a variety of side effects. So research on preparing new analgesic agents is important. According to some reports about the analgesic activity of hydrazide and hydrazine derivatives a new series of these compounds were synthesized in order to obtain new analgesic compounds. The final compounds 10a-10e and 15a-15d were prep...

We discuss the appropriate techniques for modelling the geometry of open ended elastic polymer molecules. The molecule is assumed to have fixed endpoints on a boundary surface. In particular we discuss the concept of the winding number, a directional measure of the linking of two curves, which can be shown to be invariant to the set of continuous deformations vanishing at the polymer's end-poin...

Reflex-based procedures are important measures in preclinical pain studies that evaluate stimulated behaviors. These procedures, however, are insufficient to capture the complexity of the pain experience, which is often associated with the depression of several innate behaviors. While recent studies have made efforts to evidence the suppression of some positively motivated behaviors in certain ...

In the present study, the antinociceptive profiles of Campanula punctata extract were examined in ICR mice. The Campanula punctata contain a large dose of saponin. Campanula punctata extract administered orally (200 mg/kg) showed an antinociceptive effect as measured by the tail-flick and hot-plate tests. In addition, Campanula punctata extract attenuated the writhing numbers in the acetic acid...

BACKGROUND There is evidence supporting the antinociceptive effects of carbamazepine, oxcarbazepine, gabapentin, and topiramate in various models of neuropathic pain as well as inflammatory somatic pain. Data are lacking on the antinociceptive potential of these drugs against visceral pain. In this study, we examined and compared the effects of carbamazepine, oxcarbazepine, gabapentin, and topi...