These include: References http://bmj.com/cgi/content/full/328/7432/152#otherarticles 3 online articles that cite this article can be accessed at: http://bmj.com/cgi/content/full/328/7432/152#BIBL This article cites 2 articles, 1 of which can be accessed free at: Rapid responses http://bmj.com/cgi/eletter-submit/328/7432/152 You can respond to this article at: http://bmj.com/cgi/content/full/328...

CD44 is frequently overexpressed in a wide variety of epithelial malignancies including gastrointestinal cancer and causes resistance to currently available treatments. MicroRNAs (miRNAs) are non-coding RNAs that regulate molecular pathways in cancer by targeting various genes. The aim of this study was to investigate the regulation of CD44 expression by miRNAs and to develop new molecular targ...

Morphogenesis is crucial to initiate physiological development and tumor invasion. Here we show that a microRNA controls zonation morphogenesis by targeting hyaluronan receptor CD44. We have developed a novel system to study microRNA functions by generating constructs expressing pre-miRNAs and mature miRNAs. Using this system, we have demonstrated that expression of miR-328 reduced cell adhesio...

EZH2 is up-regulated in various cancer types, implicating its role in tumorigenesis. Our recent data have shown that repression of EZH2 inhibited glioma growth by inhibition β-catenin signaling. Here, we identified several miRNAs that were repressed by EZH2, which in turn regulate β-catenin expression by its 3'UTR, such as miR-1224-3p, miR-328 and miR-214. Further, EZH2 silenced miR-328 express...

Abstract . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 317 1. Methods . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 319 1.1 Search Strategy . . . . . . . . . . ....

MicroRNAs (miRNAs) are believed to be resistant against radiotherapy in certain types of cancers. The aim of our study was to determine the clinical application of miRNAs in non-small cell lung cancer (NSCLC). Sixty NSCLC tissue samples and adjacent histologically normal tissues were obtained for miRNAs microarray analysis and validated by RT-qPCR. Correlation between miRNA expression level and...

MicroRNAs (miRNAs) have been recognized to mediate PDGF-induced cell dysregulation, but their exact functions remain to be elucidated. By using a sensitive S-Poly(T) Plus qRT-PCR method, the expression profiling of 1,078 miRNAs were investigated in pulmonary artery smooth muscle cells (PASMCs) with or without PDGFBB stimulation. MiR-328 was found as a prominent down-regulated miRNA, displaying ...

Promotion of Apoptosis Does Not Necessarily Mean Inhibition of Remodeling To the Editor: Hypoxic pulmonary hypertension is a serious disease characterized by hypoxic pulmonary vasoconstriction and pulmonary vascular remodeling. In the article “The MicroRNA-328 Regulates Hypoxic Pulmonary Hypertension by Targeting at Insulin Growth Factor 1 Receptor and l-Type Calcium Channel-1C,” the authors ha...

OBJECTIVE Recent studies have revealed that microRNAs (miRNAs) are involved in the regulation of cardiac development, physiologic, and pathologic processes via post-transcriptional control of gene expression. The stable circulating miRNAs offer unique opportunities for the early diagnosis of several diseases. In this study, we examined the circulating miR-133 and miR-328 levels from patients wi...

http://bmj.com/cgi/content/full/328/7446/988 Updated information and services can be found at: These include: Data supplement http://bmj.com/cgi/content/full/bmj.38070.503009.EE/DC1 "Security statement" References http://bmj.com/cgi/content/full/328/7446/988#otherarticles 6 online articles that cite this article can be accessed at: http://bmj.com/cgi/content/full/328/7446/988#BIBL This article ...