Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra (SN) and the appearance of fibrillar aggregates of insoluble α-synuclein (α-syn) called Lewy bodies (LBs). Approximately 90% of α-syn deposited in LBs is phosphorylated at serine 129 (Ser129). In contrast, only 4% of total α-syn is phosphorylated in normal brain, suggesting that accumulation of...

The Palaearctic species of the common and speciose fairyfly genus Gonatocerus Nees ab Esenbeck (Hymenoptera: My-maridae) are reviewed. Illustrated identification keys are provided to separate the three subgenera of Gonatocerus that oc-cur in the region and to females of the species in each subgenus. Distribution ranges, including new records of extralimital specimens examined, and known host as...

Aggregation of α-synuclein (α-syn) is associated with the development of a number of neurodegenerative diseases, including Parkinson's disease (PD). The formation of α-syn aggregates results from aberrant accumulation of misfolded α-syn and insufficient or impaired activity of the two main intracellular protein degradation systems, namely the ubiquitin-proteasome system and the autophagy-lysoso...

Current Linux kernels include a facility called TCP SYN cookies, conceived to face SYN flooding attacks. However, the current implementation of SYN cookies does not support the negotiation of TCP options, although some of them are relevant for throughput performance, such as large windows or selective acknowledgment. In this paper we present an improvement of the SYN cookie protocol, using all ...

Machines that provide TCP services are often susceptible to various types of Denial of Service attacks from external hosts on the network. One particular type of attack is known as a SYN flood, where external hosts attempt to overwhelm the server machine by sending a constant stream of TCP connection requests, forcing the server to allocate resources for each new connection until all resources ...

An updated revision of Oriental Dryinidae is presented. Seven subfamilies, 20 genera and 368 species are treated. Eight new species are described: Aphelopus zonalis Xu, Olmi & He, sp. nov. (China, Hainan); Anteon zoilum Xu, Olmi & He, sp. nov. (China, Yunnan), Anteon zonarium Xu, Olmi & He, sp. nov. (China, Yunnan), Anteon zopyrum Xu, Olmi & He, sp. nov. (China, Xizang), Anteon zoroastrum Xu, O...

The discovery that alpha-synuclein (α-syn) is the primary component of the neuropathological hallmarks of Parkinson's disease (PD) and the identification of α-syn mutations in numerous inherited forms of PD has positioned α-syn at the top of the list of important factors in the pathogenesis of PD. Based on the pathological accumulation of α-syn in the brains of patients, the field is currently ...

The proposal in this document is experimental. While it may be deployed in the current Internet, it does not represent a consensus that this is the best possible mechanism for the use of ECN in TCP SYN/ACK packets. This draft describes an optional, experimental modification to RFC 3168 to allow TCP SYN/ACK packets to be ECN-Capable. For TCP, RFC 3168 only specifies setting an ECN-Capable codepo...