The overall aim of the present study was to widen our knowledge about the biopharmaceutical behaviour of novel hydroxypropyl methylcellulose (HPMC)-based two-piece capsules by comparing them with the classic hard gelatine capsules. Firstly, the tendency of the HPMC capsules to stick to isolated porcine oesophageal preparation was evaluated. The force needed to detach the HPMC capsules from the ...

A generalized silica coating scheme is used to functionalize and protect sub-micron and micron size dicyclopentadiene monomer-filled capsules and polymer-protected Grubbs' catalyst particles. These capsules and particles are used for self-healing of microscale damage in an epoxy-based polymer. The silica layer both protects the capsules and particles, and limits their aggregation when added to ...

Multilayer polyelectrolyte capsules made by layer-by-layer assembly of oppositely charged biodegradable polyelectrolytes were filled with a model of a nonactive prodrug, a self-quenched fluorescence-labeled protein. After capsule uptake by living cells, the walls of the capsules were actively degraded and digested by intracellular proteases. Upon capsule wall degradation, intracellular protease...

Chiral capsules with polar interiors (reversed capsules) undergo heterochiral sorting and exhibit positive mutalism - both hemispheres mutually benefit from the association. This feature can be coupled with partial reversibility of the formation reaction and utilized to amplify synthesis of hybrid capsules made of hemispheres that cannot be formed independently.

Abstract This work reports on the self-healing capabilities of mortar specimens with polyurethane encapsulated in two types cementitious macro-capsules, by comparison performance using same healing agent glass capsules, as tested an inter-laboratory testing campaign following a pre-standard procedure. was performed twofold objective checking robustness such procedure for varying capsules and ef...

Towards the goal of development of a generic nanomaterial delivery system and delivery of the 'as prepared' nanoparticles without 'further surface modification' in a generic way, we have fabricated a hybrid polymer capsule as a delivery vehicle in which nanoparticles are loaded within their cavity. To this end, a generic approach to prepare nanomaterials-loaded polyelectrolyte multilayered (PEM...

A novel and facile method was developed to produce hybrid graphene oxide (GO)-polyelectrolyte (PE) capsules using erythrocyte cells as templates. The capsules are easily produced through the layer-by-layer technique using alternating polyelectrolyte layers and GO sheets. The amount of GO and therefore its coverage in the resulting capsules can be tuned by adjusting the concentration of the GO d...

We propose refinement laws for the top level design elements of Real Time UML (UML-RT): classes and capsules. These laws can be used to develop concrete design models from abstract analysis models. Laws for introducing and decomposing classes and capsules are presented. Standard data refinement techniques are adapted for classes, and process refinement techniques for capsules. We also propose t...