We investigated the conformational change in the human prion protein owing to an Ala→Val mutation by using molecular dynamics simulations. This mutation is related to Gerstmann-Sträussler-Sheinker disease, one of the familial prion diseases. Five prion protein structures were simulated in the periodic or non-periodic system. The results of molecular dynamics calculations indicated that the glob...

We have, by now, seen the various uses of game theory in different aspects of networking like bandwidth trading, MAC Layer access, congestion control, etc. In this lecture, we will see how routing is modeled using game theory.

Experimental Biology and Medicine Bernd Mayer Ernst R. Werner, Antonius C.F. Gorren, Regine Heller, Gabriele Werner-Felmayer and Tetrahydrobiopterin and Nitric Oxide: Mechanistic and Pharmacological Aspects 2003, 228:1291-1302. Experimental Biology and Medicine http://ebm.rsmjournals.com/content/228/11/1291 Updated information and services can be found at: http://ebm.rsmjournals.com/content/228...

Experimental Biology and Medicine William B. Pratt and David O. Toft Chaperone Machinery Regulation of Signaling Protein Function and Trafficking by the hsp90/hsp70-Based 2003, 228:111-133. Experimental Biology and Medicine http://ebm.rsmjournals.com/content/228/2/111 Updated information and services can be found at: http://ebm.rsmjournals.com/content/228/2/111#BIBL This article cites 304 artic...

Experimental Biology and Medicine Magnus M. Berglund, Philip A. Hipskind and Donald R. Gehlert Peptide Receptor Subtypes Recent Developments in Our Understanding of the Physiological Role of PP-Fold 2003, 228:217-244. Experimental Biology and Medicine http://ebm.rsmjournals.com/content/228/3/217 Updated information and services can be found at: http://ebm.rsmjournals.com/content/228/3/217#BIBL ...

Lung cancer rates and mortality have risen m epidemic proportions in the United States and other industrialized nations during the 20th century. Case-control and cohort studies performed in the 1950s and 1960s firmly established cigarette smoking as the single greatest risk factor for lung cancer. In the United States, overall lung cancer mortality rates in men and women rose progressively from...

Research studies suggest that a smaller proportion of women with angina (crushing chest pain) have coronary artery disease (CAD) than men with angina. This may have contributed to the perception that chest pain is less serious in women. However, CAD risk is raised in certain women with angina. This is particularly true for women who have a poor cardiovascular risk profile and more physical symp...

Background: Oxidative stress forms the foundation for the induction of multiple cellular pathways which can lead to the complications of diabetes mellitus that the most debilitating ones are diseases of the nervous system. In this study, we evaluated whether treadmill running could alleviate oxidative stress and apoptosis rate in the hippocampus of streptozotocininduced diabetic rats. Methods: ...